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化学学报
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化学学报 ›› 1998, Vol. 56 ›› Issue (6): 618-624. 上一篇    

研究论文

3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-6-烷基/芳基-均三唑并[3, 4-b]-1, 3, 4-噻二唑的合成

刘方明;于建新;刘育亭;陈耀祖   

  1. 新疆大学化学系;浙江大学化学系
  • 发布日期:1998-06-15

Synthesis of 3-(2'-phenyl-1', 2', 3'-triazole-4'-yl)-6-alkyl/aryl-s-triazolo[3, 4-b]-1, 3, 4-thiadiazoles

LIU FANGMING;YU JIANXIN;LIU YUTING;CHEN YAOZU   

  • Published:1998-06-15

PDF

523

被引次数

19

研究了3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-4-氨基-5-巯基-1, 2, 4-三唑(1)与取代苯甲酸和脂肪酸(2a-r)在POCl3催化下的反应, 共合成得到18个新的3-(2'-苯基-1', 2', 3'-连三唑-4'-基)-6-烷基/芳基-均三唑并[3, 4-b]-1, 3, 4-噻二唑(3a-r), 经元素分析,IR, 1H NMR和MS进行了结构确证。

关键词: 生物活性, 红外分光光度法, 元素分析, 质谱法, 质子磁共振谱法, 噻二唑 P, 三唑 P

Condensation of 3-(2'-phenyl-1', 2', 3'-triazole-4'-yl)-4-amino-5-mercapto-1, 2, 4-triazole(1) with alkyl or aryl acids (2a-r) in the presence of phosphorus oxychloride gave 18 novel 3-(2'-phenyl-1', 2', 3'-triazole-4'-yl)-6-alkyl/aryl-s-triazolo[3, 4-b]-1, 3, 4-thiadiazoles (3a-r). Their structures were confirmed by elemental and spectral analyses.

Key words: BIOLOGICAL ACTIVITY, INFRARED SPECTROPHOTOMETRY, ELEMENTAL ANALYSIS, MASS SPECTROGRAPHY, PROTON MAGNETIC RESONANCE SPECTROMETRY, THIADIAZOLE P, PYRRODIAZOLE P

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