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化学学报
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化学学报 ›› 2002, Vol. 60 ›› Issue (6): 1095-1101. 上一篇    下一篇

研究论文

新型含2-苯基-1,2,3-三唑基的1,5-苯并硫氮杂??及其β-内酰胺衍生物的合成

刘方明;王宝雷;张正方;孙万赋   

  1. 新疆大学化学与化工学院,乌鲁木齐(830046);南开大学元素有机化学研究所. 天津(300071)
  • 发布日期:2002-06-15

Synthesis of New 1,5-benzothiazepines Containing 2-Phenyl-1,2,3- triazole and Their β-Lactams Derivatives

Liu Fangming;Wang Baolei;Zhang Zhengfang;Sun Wanfu   

  1. College of Chemistry and Chemical Engineering, Xingjiang University, Wulumuqi(830046);Institute of Elemento-organic Chemistry, Nankai University.Tianjin(300071)
  • Published:2002-06-15

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α,β-不饱和酮(1a～1e)与邻氨基苯硫酚反应，得到含2-苯基-1,2,3-三唑基 的1,5-苯并硫氮杂？？(2a～2e)，然后以其为原料与烯酮“现场”进行[2+2]环加 成，合成础一系列含2-苯基-1,2,3-三唑基的β-内酰胺并合的1,5-苯并硫氮杂？？ 衍生物(3a～3j)。产物经~1H NMR，IR，元素分析及MS加以确证。

关键词: 苯硫酚, 三唑 P, 内酰胺, 环加成反应, 质子磁共振谱法, 红外分光光度法, 元素分析, 质谱法, 苯并硫代杂卓 P

1,5-benzothiazepines Containing 2-Phenyl-1,2,3-triazole (2a～2e) were synthesized from α,β-unsaturated ketones and 2-aminothiophenol. The benzothiazepines could undergo [2+2] cycloaddition reaction with ketenes generated in situ to give a series of β-lactams derivatives. The structure of products were established by IR, ~1H NMR, MS spectroscopy and elementary analysis.

Key words: BENZENETHIOL, PYRRODIAZOLE P, LACTAM, CYCLOADDITION REACTION, 1HNMR, IR, ELEMENTAL ANALYSIS, MS, BENZOTHIAZEPINE P

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