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化学学报
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化学学报 ›› 2005, Vol. 63 ›› Issue (12): 1069-1074. 上一篇    下一篇

研究论文

含有金刚烷胺的多金属氧酸盐的合成和抗流感病毒活性

刘术侠*1 2，王春玲1，于淼1，李玉新2，王恩波1   

  1. (东北师范大学 1多酸研究所 2遗传与细胞研究所 长春 130024)
  • 投稿日期:2004-11-17 修回日期:2005-02-26 发布日期:2010-12-10
  • 通讯作者: 刘术侠

Synthesis and Anti-influenza Virus Activity of Polyoxometalates Containing Amantadine

LIU Shu-Xia*1,2, WANG Chun-Ling1, YU Miao1, LI Yu-Xin2, WANG En-Bo1   

  1. (1 Institute of Polyoxometalate Chemistry, 2 Institute of Cytology and Genetics Research, Northeast Normal University, Changchun 130024)
  • Received:2004-11-17 Revised:2005-02-26 Published:2010-12-10
  • Contact: LIU Shu-Xia

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2054

被引次数

74

以金刚烷胺和1∶10 (Ln∶W), 1∶13(Ni或Mn∶V)系列多金属氧酸盐为原料, 合成了化学式分别为K4(C10H18N)5CeW10O36•2H2O (APOM-5), K4(C10H18N)5PrW10O36•2H2O (APOM-6), K3(C10H18N)4NiV13O38•H2O (APOM-12)和K3(C10H18N)4MnV13O38•H2O (APOM-13)的四种新的多金属氧酸盐, 并通过元素分析、IR光谱及1H NMR谱对其结构进行了表征. 在狗肾(Madin-Darby canine kidney, MDCK)细胞内, 对合成化合物进行了抗流感病毒A和B的活性研究. 发现APOM-13对流感病毒A, B两型均有明显的抑制活性, 而APOM-12只在浓度较高时对流感病毒A, B两型有抑制活性, 低浓度时, 活性不明显. APOM-5,6对A型流感病毒有效, 但对B型流感病毒抑制活性不明显. 另外发现APOM-12和APOM-13对流感病毒感染MDCK细胞病变效应(CPE)具有明显抑制作用, 且浓度越大抑制作用愈明显.

关键词: 金刚烷胺, 多金属氧酸盐, 抗流感病毒活性

Four novel polyoxometalates constructed from amantadine and a series of polyoxometalates [1∶10 (Ln∶W) and 1∶13 (Ni or Mn∶V)], which can be formulated as K4(C10H18N)5CeW10O36•2H2O (APOM-5), K4(C10H18N)5PrW10O36•2H2O (APOM-6), K3(C10H18N)4NiV13O38•H2O (APOM-12) and K3(C10H18N)4MnV13O38•H2O (APOM-13) respectively, have been synthesized and characterized by elemental analysis, IR and 1H NMR spectroscopy methods. The antivirus activity of the synthesized compounds was investigated on the inhibitory effect against both influenza types A and B in Madin-Darby canine kidney (MDCK). It indicates that APOM-13 had significant inhibitory activity against both A and B and APOM-12 had inhibitory activity against both A and B only in high concentration but it was not remarkable in low concentration. APOM-5 and APOM-6 have effectively activity against influenza A but not significantly towards B. In addition, it was found that APOM-12 and APOM-13 exhibited good inhibitory effect on MDCK cytopathogenic effect (CPE) that was infected with influenza virus and the inhibitory activity was more evident in higher concentration.

Key words: amantadine, polyoxometalate, anti-influenza virus activity