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化学学报
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化学学报 ›› 2005, Vol. 63 ›› Issue (9): 834-840. 上一篇    下一篇

研究论文

聚酰胺类DNA识别分子质谱的碎裂机理

李钦玲1 2，周江1，汤菲力1，袁谷*1   

  1. (1北京大学化学学院 化学生物学系 生物有机与分子工程教育部重点实验室 北京 100871)
    (2青海民族学院化学系 西宁 810007)
  • 投稿日期:2004-08-03 修回日期:2005-01-11 发布日期:2010-12-10
  • 通讯作者: 袁谷

ESI-mass Spectral Fragmentation Pathways of DNA Recognizing Polyamides

LI Qin-Ling2, ZHOU Jiang1, TANG Fei-Li1, YUAN Gu*1   

  1. (1Department of Chemical Biology, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871)
    (2Department of Chemistry, Qinghai University for Nationalities, Xi'ning 810007)
  • Received:2004-08-03 Revised:2005-01-11 Published:2010-12-10
  • Contact: YUAN Gu

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1462

被引次数

13

采用ESI-MS法研究了8个含有N-甲基吡咯(Py)和N-甲基咪唑(Im)杂环的聚酰胺质谱的特征和碎裂机理. MSn数据表明, 聚酰胺化合物的主要碎裂路径是环与环间化学键的断裂, 即C—CO键、CO—NH键、HN—C键的断裂, 同时伴随着H原子的重排. 利用这些碎裂特征, 可以得到聚酰胺丰富的结构信息和区分它们的两种同分异构体.

关键词: 聚酰胺, ESI-质谱法, 碎裂特征和机理

Mass spectral fragmentation mechanisms of eight polyamides containing N-methylpyrrole and N-methylimidazole were investigated by electrospray ionization tandem mass spectrometry. The ESI-MSn data show that the principal fragmentation pathways of the polyamides are the cleavage of C—CO, CO—NH and NH—C bonds of the amide groups, or together with rearrangement of hydrogen atom. The differences of the ESI mass spectra suggest the structural information of polyamides, and the two isomers were distinguished by ESI-MS.

Key words: polyamide, ESI mass spectrometry, fragmentation pathway