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化学学报
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化学学报 ›› 2006, Vol. 64 ›› Issue (7): 589-592.    下一篇

研究论文

海藻硫酸多糖抑制草酸钙结石形成的化学模拟

邓穗平1，欧阳健明*,1,2，吴秀梅1，王凤新1，岑颖洲2   

  1. (1暨南大学生物矿化与结石病防治研究所 广州 510632)
    (2暨南大学化学系 广州 510632)
  • 投稿日期:2005-07-01 修回日期:2005-12-02 发布日期:2006-04-15
  • 通讯作者: 欧阳健明

Chemical Simulation on Inhibition of Calcium Oxalate Stones by Eucheuma striatum Polysaccharide

DENG Sui-Ping1, OUYANG Jian-Ming*,1,2, WU Xiu-Mei1, WANG Feng-Xin1, CEN Ying-Zhou2   

  1. (1 Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632)
    (2 Department of Chemistry, Jinan University, Guangzhou 510632)
  • Received:2005-07-01 Revised:2005-12-02 Published:2006-04-15
  • Contact: OUYANG Jian-Ming

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1008

被引次数

15 | 3

用体外模拟方法研究了从海藻异枝麒麟菜中提取的硫酸多糖(ESPS)对尿结石患者尿液中草酸钙晶体生长的影响. ESPS不但诱导与尿路细胞膜粘附力较弱的二水草酸钙晶体形成, 而且抑制一水草酸钙的生长和聚集, 归因于一水草酸钙的富钙(101)晶面与聚阴离子ESPS之间的静电相互作用. 上述结果表明, ESPS是一种抑制草酸钙结石的潜在绿色药物.

关键词: 草酸钙, 海藻多糖, 尿结石

The influence of sulfated polysaccharide (ESPS) isolated from marine algae Eucheuma striatum on crystallization of calcium oxalate crystals was investigated in urine of lithogenic patient in vitro. SPS could inhibit the growth and aggregation of calcium oxalate monohydrate (COM) and induce the formation of calcium oxalate dihydrate crystals due to the strong electrostatic interactions between the Ca2＋-rich (101) crystal faces of COM and the polyanionic polysaccharide. This result indicated that SPS may be a potential inhibitor to calcium oxalate urinary stones.

Key words: calcium oxalate, algal polysaccharide, urinary stone