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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (1): 49-52. 上一篇    下一篇

研究论文

马钱子中两种微量生物碱异构体的电喷雾多级串联质谱分析

闫静1,2, 刘志强*,1, 朱海光2, 刘淑莹1   

  1. (1中国科学院长春应用化学研究所长春质谱中心 长春 130022)
    (2黑龙江中医药大学药学院 哈尔滨 150040)
  • 投稿日期:2006-04-03 修回日期:2006-08-02 发布日期:2007-01-14
  • 通讯作者: 刘志强

Analysis of Two Trace Alkaloid Isomers in Strychnos nux-vomical by Electrospray Ionization Tandem Mass Spectrometry

YAN Jing1,2; LIU Zhi-Qiang*,1; ZHU Hai-Guang2; LIU Shu-Ying1   

  1. (1 Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun Center of Mass Spectrometry, Changchun 130022)
    (2 College of Pharmacy, Heilongjiang University of Traditional Chinese Medicine, Harbin 150040)
  • Received:2006-04-03 Revised:2006-08-02 Published:2007-01-14
  • Contact: LIU Zhi-Qiang

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被引次数

12 | 1

采用电喷雾多级串联质谱方法, 通过分子量和多级串联质谱的信息对马钱子总生物碱提取物中微量生物碱异构体伪士的宁、士的宁氮氧化物进行了分析研究; 并研究了异构体质谱碎裂规律与结构之间的关系. 建立了马钱子中生物碱同分异构体区分的简便、快速、灵敏的新方法.

关键词: 伪士的宁, 士的宁氮氧化物, 电喷雾多级串联质谱

According to their molecular mass and ESI-MSn data, the trace alkaloid isomers pseudostrychnine and strychnine N-oxide in extracts of the total alkaloids from Strychnos nux-vomical were qualitatively analyzed by electrospray ionization tandem mass spectrometry (ESI-MSn) method after rough silica gel-column chromatographic separation. We also investigated the relationship between their fragmentation mechanism and structures of the two alkaloid isomers. A new method for quickly and highly sensitively analyzing the two alkaloid isomers was proposed.

Key words: pseudostrychnine, strychnine N-oxide, electrospray tandem mass spectrometry