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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (16): 1638-1642. 上一篇    下一篇

研究论文

大叶橐吾中三个新的艾里莫芬型倍半萜

沈彤, 李平林, 袁呈山*, 贾忠建*   

  1. (兰州大学化学化工学院 功能有机分子化学国家重点实验室 兰州 730000)
  • 投稿日期:2007-04-04 修回日期:2007-07-05 发布日期:2007-08-28
  • 通讯作者: 袁呈山, 贾忠建

Three New Eremophilane-Type Sesquiterpenes from Ligularia macrophylla

SHEN Tong; LI Ping-Lin; YUAN Cheng-Shan*; JIA Zhong-Jian*   

  1. (State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000)
  • Received:2007-04-04 Revised:2007-07-05 Published:2007-08-28
  • Contact: YUAN Cheng-Shan; JIA Zhong-Jian

PDF

822

被引次数

27

从大叶橐吾的根部分离得到三个新的艾里莫芬型倍半萜(1, 2和3), 经多种波谱方法和单晶X射线衍射确定它们的结构分别为: 6α,15β-环氧-8β-羟基-艾里莫芬-7(11)-烯-8α,12-内酯(1), 7-乙酰基-13β-羧酸-6(7)-烯-降-艾里莫芬烷(2), 艾里莫芬-7(11)-烯-6α,15β-内酯(3). 此外, 对化合物1进行了抗菌和抗癌活性测试.

关键词: 大叶橐吾, 菊科, 艾里莫芬型倍半萜, 单晶X射线衍射

Three new eremophilane-type sesquitererpenes (1, 2 and 3) were isolated from the roots of Ligularia macrophylla. On the basis of spectroscopic methods including 2D NMR and X-ray diffraction experiment, their structures were elucidated as 6α,15β-epoxy-8β-hydroxy-7(11)-8α,12-olide (1), 7-acetyl-6(7)-en-nor- eremophil-13β-carboxylic acid (2) and eremophil-7(11)-en-6α,15β-olide (3). In addition, antibacterial activity and cytotoxicity activity of compound 1 were tested.

Key words: Ligularia macrophylla, Compositae, eremophilane-type sesquiterpene, X-ray diffraction