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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (16): 1679-1684. 上一篇    下一篇

研究论文

短柄雪胆中的三萜葫芦素及其皂苷

陈剑超, 张重权, 邱明华*   

  1. (中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室 昆明 650204)
  • 投稿日期:2007-03-27 修回日期:2007-06-03 发布日期:2007-08-28
  • 通讯作者: 邱明华

Chemical Constituents from the Tubers of Hemsleya delavayi

CHEN Jian-Chao; ZHANG Zhong-Quan; QIU Ming-Hua*   

  1. (State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204)
  • Received:2007-03-27 Revised:2007-06-03 Published:2007-08-28
  • Contact: QIU Ming-Hua

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从短柄雪胆的块根中分离得到了14个三萜葫芦素类化合物. 经波谱分析及化学方法鉴定了它们的结构, 其中有新化合物5个, 分别命名为短柄雪胆苷A～E (1～5), 以及肉花雪胆苷元A (6), 藤三七雪胆苷R8 (7), 肉花雪胆苷I (8), 肉花雪胆苷II (9), 肉花雪胆苷III (10), 雪胆甲素(11), 雪胆乙素(12), 雪胆甲素苷(13), 藤三七雪胆苷R1 (14)等9个已知化合物. 6是首次从自然界中得到的化合物.

关键词: 短柄雪胆, 葫芦科, 短柄雪胆苷A～E, 葫芦素类化合物

Fourteen cucurbitane compounds, including five new ones named delavanosides A～E (1～5), and nine known ones identified as carnosiflogenin A (6), scandenoside R8 (7), carnosifloside I (8), carnosifloside II (9), carnosifloside III (10), hemslecin A (11), hemslecin B (12), 2-O-β-D-glycoside of hemslecin A (13) and scandenoside R1 (14), were isolated from the tubers of Hemsleya delavayi. On the basis of spectral analysis and chemical methods, the new compounds were elucidated as 3β,27-dihydroxycucurbita-5,24-dien- 11-on-27-O-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (1), 3β,20,27-trihydroxycucurbita-5,24-dien- 11-on-27-O-β-D-glucopyranosyl(1®2)-b-D-glucopyranoside (2), 3β,20,27-trihydroxycucurbita-5,24-dien- 11-on-3-O-β-D-glucopyranosyl-27-O-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (3), 3β,26-dihydroxy- cucurbita-5,24-dien-11-on-3-O-β-D-glucopyranoside (4) and 3β,26-dihydroxycucurbita-5,24-dien-11-on-3- O-β-D-glucopyranosyl-26-O-β-D-glucopyranosyl(1®6)-β-D-glucopyranosyl(1®2)-β-D-glucopyranoside (5). Compound 6 was also firstly isolated as a natural product.

Key words: Hemsleya delavayi, Cucurbitaceae, delavanoside A～E, cucurbitane compound