化学学报 ›› 2007, Vol. 65 ›› Issue (17): 1863-1868. 上一篇    下一篇

研究论文

玻璃微流控芯片廉价快速制作方法的研究

陈强1,2, 李刚1,2, 潘爱平3, 金庆辉1, 赵建龙*,1, 程建功1, 徐元森1   

  1. (1中国科学院上海微系统与信息技术研究所 上海 200050)
    (2中国科学院研究生院 北京100039)
    (3南通大学附属医院 南通 226001)
  • 投稿日期:2007-02-06 修回日期:2007-05-14 发布日期:2007-09-14
  • 通讯作者: 赵建龙

Study on a Low-cost and Fast Fabrication Method of Glass Microflu-idic Chips

CHEN Qiang1,2; LI Gang1,2; PAN Ai-Ping3; JIN Qing-Hui1; ZHAO Jian-Long*,1; CHENG Jian-Gong1; XU Yuan-Sen1   

  1. (1 Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sci-ences, Shanghai 200050)
    (2 Graduate School of Chinese Academy of Sciences, Bei-jing 100039)
    (3 Affiliated Hospital of Nantong University, Nantong 226001)
  • Received:2007-02-06 Revised:2007-05-14 Published:2007-09-14
  • Contact: ZHAO Jian-Long

研究了一种玻璃微流控芯片的快速、低成本制作工艺和方法. 该方法采用商品化的显微载玻片(soda-lime玻璃)作为芯片基质材料, 利用AZ 4620光刻胶代替传统工艺中的溅射金属层或多晶硅/氮化硅层作为玻璃刻蚀的掩膜层, 同时利用一种紫外光学胶键合方法代替传统熔融键合方法实现芯片的键合, 整个工艺对玻璃基质材料要求低, 普通微流控芯片(深度小于50 μm)制作流程仅需约3.5 h, 可降低制作成本, 缩短制作周期. 还系统地研究了光刻胶厚度、光刻胶硬烘时间和玻璃腐蚀液配比对玻璃微流控芯片制作的影响, 获得了优化的工艺参数.

关键词: 微流控芯片, 湿法刻蚀, 紫外胶键合, 微加工技术

This paper describes a low-cost, fast process for the fabrication of glass microfluidic chips, in which commercially-available microscope glass slides (soda-lime glass) were used as substrate materials, and a layer of AZ 4620 positive photoresist was used as an etch mask for buffered oxide etching of soda-lime glass instead of using an expensive metal or polysilicon/nitride layer. Meanwhile, a fast but reliable UV-bonding process was developed to seal the channels rather than utilizing thermal fusion bonding. The whole process for most microfluidic devices (<50 μm in depth) could be done within 3.5 h, which greatly decreases the time and cost of the fabrication of the glass microfluidic devices. Here the effects of the thickness of the photoresist, hardbake time and ratio of BOE on the fabrication of the glass microfluidic chips were also systemically investigated. Some optimum parameters were achieved for the fabrication process.

Key words: microfluidic chip, wet-etching, UV bonding, microfabrication