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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (4): 465-470. 上一篇    下一篇

研究论文

调控发光波长: 新型2-取代8-羟基喹啉衍生物金属锌配合物的合成与特性研究

张卫民, 曾和平*   

  1. (华南理工大学化学科学学院功能分子研究所 广州 510641)
  • 投稿日期:2007-06-30 修回日期:2007-09-10 发布日期:2008-02-28
  • 通讯作者: 曾和平

Tuning Wavelength: Synthesis and Properties of 2-Substituted 8-Hydroxyquinoline Derivatives with Zinc(II) Complexes

ZHANG Wei-Min; ZENG He-Ping*   

  1. (Institute of Functional Molecule, School of Chemistry, South China University of Technology, Guangzhou 510641)
  • Received:2007-06-30 Revised:2007-09-10 Published:2008-02-28

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被引次数

34 | 5

设计合成了2-[(2'-芴基)-乙烯基]-8-羟基喹啉(6)、2-[(2'-菲基)-乙烯基]-8-羟基喹啉(7)及其金属锌配合物8和9; 用UV-Vis, FT-IR, ESI-MS, 1H NMR和元素分析确认了化合物6和7的结构; 并用四甲基偶氮唑盐微量酶反应比色法(MTT法)研究了其调控骨髓间质干细胞增殖的作用, 结果表明, 化合物6和7对干细胞有明显的增殖作用. 用FT-IR, FAB-MS和元素分析表征了金属锌配合物结构, 光致发光光谱测试结果表明, 化合物8的发光峰值为602 nm, 发黄光; 化合物9的发光峰值为628 nm, 发橙红色光.

关键词: 8-羟基喹啉, 骨髓间质干细胞, 荧光光谱

The 2-(2-(9H-fluoren-2-yl) vinyl)-8-hydroxyquinoline (6) and 2-(2-(phenanthren-9-yl) vinyl)-8-hydroxyquinoline (7) and their zinc complexes 8 and 9 have been synthesized. Compounds 6 and 7 were confirmed by UV-Vis, FT-IR, ESI-MS, 1H NMR and elemental analysis. Regulation of the mesenchymal stem cells by compounds 6 and 7 have been evaluated by MTT assay, and the results show that these compounds have the ability to induce the proliferation of the mesenchymal stem cells. The zinc complexes were determined by FT-IR, FAB-MS and elemental analysis. Photoluminescence spectra show that the emission peaks of compounds 8 and 9 are at 602 and 628 nm, with yellow and red light emitted, respectively.

Key words: 8-hydroxyquinoline, mesenchymal stem cell, fluorescence spectra