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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (23): 2697-2702. 上一篇    下一篇

研究论文

介孔球状纳米羟基磷灰石的多级组装合成

宋 琳a，朱大章b，孙晓宇a，汪世龙a，孙冬梅*,a   

  1. (a同济大学生命科学与技术学院 上海 200092) (b同济大学化学系 上海 200092)
  • 投稿日期:2009-04-10 修回日期:2009-07-08 发布日期:2009-08-10
  • 通讯作者: 孙冬梅 E-mail:sundongmei@mail.tongji.edu.cn
  • 基金资助:

    国家自然科学基金项目（No.50802063）；教育部科学技术研究重点项目（No.109058）

Multi-level assembly and synthesis of Spherical meso-level outlet hydroapatite nanoparticles

Song, Lina，Zhu, Dazhangb，Sun, Xiaoyua，Wang, Shilonga，Sun, Dongmei*,a   

  1. (a School of Life Science & Technology, Tongji University, Shanghai 200092) (b Department of Chemistry, Tongji University, Shanghai 200092)
  • Received:2009-04-10 Revised:2009-07-08 Published:2009-08-10

PDF

2202

被引次数

9

利用支撑液膜控制离子在隔离的两相中流动传输, 同时添加有机小分子协同液膜界面形成模板, 诱导纳米晶体进行嵌段组合团聚成非致密型超结构, 得到一种由纳米片状亚单元卷曲后组装形成的新型介孔球状纳米羟基磷灰石材料. TEM, XRD, BET等结果表明, 产物纳米羟基磷灰石平均孔径为17.5 nm. 细胞毒性实验表明, 不同浓度的细胞存活率高于80%, 细胞毒性为1级, 可认为材料具有良好的细胞相容性. FT-IR, UV光谱结果表明产物能有效的对鬼臼毒素进行载药包裹, 平均载药量为12.9%, 包封率为65.5%. 这种新型介孔超结构HA在酶、蛋白质的固定和分离、药物转染等方面具有其潜在的应用价值.

关键词: 纳米羟基磷灰石, 介孔材料, 球状结构, 生物相容性

A new kind of mesoporous spherical HA nanoparticles which formed by the curling of the sheet-like subunit was obtained by supported liquid membrane (SLM) combining with small organic molecules method, in which SLM controlled the transportation of the ions between the two separated phases, and the small organic molecules cooperated with the SLM to induce the nanocrystals to combine and reunite to form noncompacted superstructure. The results of TEM, XRD and BET showed that the average pore diameter of the sample obtained was 17.5 nm. The cell toxic experiment showed that the survival ratio of different cell concentration was more than 80% and the cell toxicity of pure material was A1, which means the HA obtained has nice biocompatibility. The FT-IR and UV tests demonstrated that the material could enwrap podophyllotoxin efficiently. The average drug loading was 12.9%, and entrapment efficiency was 65.5%. In conclusion, this new kind of material has potential applications on immobilization of enzyme, protein macromolecular adsorption, catalytic reaction, drug store, and so on.

Key words: hydroapatite nanoparticles, mesoporous materials, globular particle, biocompatibility