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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (19): 2019-2023. 上一篇    下一篇

研究简报

2-(2,6-二烷氧基苯基)苯并呋喃衍生物的合成

亓金萍，曹德榕   

  1. (华南理工大学化学与化工学院 广州 510640)
  • 投稿日期:2010-04-26 修回日期:2010-06-02 发布日期:2010-06-02
  • 通讯作者: 曹德榕 E-mail:drcao@scut.edu.cn
  • 基金资助:

    国家自然科学基金项目

Synthesis of 2-(2,6-Dialkoxyphenyl)-benzo[b]furan Derivatives

QI Jin-Ping, CAO De-Rong   

  1. (School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640)
  • Received:2010-04-26 Revised:2010-06-02 Published:2010-06-02
  • Contact: Derong Cao E-mail:drcao@scut.edu.cn

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被引次数

2

以焦性没食子酸、4-羟基苯甲醛和酚为原料, 以邻碘代苯酚与苯乙炔衍生物的Sonogashira偶联及其连串化反应生成苯并呋喃环为关键步骤, 设计合成了一系列2-(2 ,6 -二烷氧基苯基)苯并呋喃衍生物, 并对产物进行了1H NMR, 13C NMR, MS等表征.

关键词: Sonogashira偶联, 2-苯基苯并呋喃, 苯并呋喃, Lespedezavirgatol

Starting from pyrogallic acid, 3,4-dimethoxyphenol, 4-hydroxybenzaldehyde and phenols, a series of 2-(2 ,6 -dialkoxyphenyl)-benzo[b]furan derivatives were designed and synthesized. The Sonogashira cross-coupling of o-iodophenol and aryl acetykenes was the key step of the synthetic route. All the new benzo[b]furan derivatives were confirmed by 1H NMR, 13C NMR and MS techniques.

Key words: Sonogashira cross-coupling, 2-phenylbenzo[b]furan, benzo[b]furan, lespedezavirgatol