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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (20): 2125-2129. 上一篇    下一篇

研究论文

聚天冬酰胺衍生物对P(MMA-GMA-DVB)微球的修饰

刘宏波*，杨卉，唐贇子，沈杨，许迁   

  1. (上海工程技术大学化学化工学院 上海 201620)
  • 投稿日期:2010-01-20 修回日期:2010-04-14 发布日期:2010-06-28
  • 通讯作者: 刘宏波 E-mail:liuhongbo81@gmail.com
  • 基金资助:

    上海市优青

Modification of P(MMA-GMA-DVB) Microspheres by Polyasparagine Derivatives

LIU Hong-Bo, YANG Hui, TANG Bin-Zi, SHEN Yang, XU Qian   

  1. (School of Chemistry & Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620)
  • Received:2010-01-20 Revised:2010-04-14 Published:2010-06-28

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1765

被引次数

4

用无皂乳液聚合法合成了不同交联剂含量(单体的20～50 wt%)的表面带环氧基团的窄分散的P(MMA-GMA- DVB) (PMGD)复合微球, 以L-天冬门酸为原料用磷酸催化溶剂法制备了聚琥珀酰亚胺(PSI), 以N,N-二甲基甲酰胺为溶剂将PSI接枝到PMGD微球表面. 元素分析结果证明, 当微球中DVB的含量为40%时, 微球表面修饰的PSI量最多. 然后用乙二胺对微球表面剩余的PSI环进行开环, 利用微球表面的氨基键合荧光素异硫氰酸荧光素(FITC), 得到了荧光微球.

关键词: 无皂乳液聚合, 聚琥珀酰亚胺, 荧光微球

Narrow-dispersed P(MMA-GMA-DVB) (PMGD) microspheres with different amout of DVB from 20 to 50 weight percentages were prepared by soap-free emulsion polymerization and polysuccinimide (PSI) was prepared by polycondensation of L-aspartic acid (L-ASP) using phosphoric acid as a catalyst in sulfolane/mesitylene solvent. Then, PSI was attached to the surface of PMGD microspheres containing different amount of DVB in N,N-dimethylformamide solvent. The elemental analysis results showed that the largest amount of PSI was attached to the surface of P(MMA-GMA-DVB) microspheres when the weight content of DVB was 40%. Then the remains of active rings of the PSI on the surface of microspheres were opened by ethanediamine, at last, fluorescent microspheres were achieved by reacting with fluorescein isothiocyanate (FITC).

Key words: soap-free emulsion polymerization, polysuccinimide, fluorescent microsphere