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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (24): 2543-2550. 上一篇    下一篇

研究论文

槲皮素金属配位印迹聚合物膜的制备及性能研究

范培民，王兵*   

  1. (天津工业大学中空纤维膜材料与膜过程省部共建国家重点实验室培育基地 环境与化学工程学院 天津 300160)
  • 投稿日期:2009-12-22 修回日期:2010-07-18 发布日期:2010-08-27
  • 通讯作者: 范培民 E-mail:fpm_597@yahoo.cn
  • 基金资助:

    国家高技术研究发展计划（863）;天津市自然科学基金

Preparation of Quercetin s Metal-complexing Imprinted Polymer Membrane and Its Properties

FAN Pei-Min, WANG Bing   

  1. (State Key Laboratory of Hollow Fiber Membrane Materials and Processes, School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300160)
  • Received:2009-12-22 Revised:2010-07-18 Published:2010-08-27
  • Supported by:

    National High Technology Research and Development Program of China (863)

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1544

被引次数

38

以中药活性成分黄酮类化合物槲皮素与Zn(II)的配合物为模板, 以4-乙烯基吡啶为功能单体, 乙二醇二甲基丙烯酸酯为交联剂, 水溶性线性聚合物聚乙二醇(PEG, Mw＝600)为添加剂, 利用分子印迹技术紫外光引发原位聚合的方法制备了带支撑的锌离子配位分子印迹聚合物膜. 使用扫描电镜测定了不同PEG用量下膜的表面形貌. 通过膜渗透实验考察了PEG含量对金属配位印迹膜渗透速率的影响, 系列印迹聚合物膜的识别体系及对不同底物的渗透选择性, 同时考察了阳离子和阴离子对印迹膜渗透模板分子的影响. 实验结果表明: 制膜过程中水溶性线性聚合物PEG的加入可以明显改善膜的透过性能|槲皮素-Zn(II)模板印迹聚合物膜对槲皮素表现出明显的渗透选择性, 对槲皮素结构类似物芦丁和柚皮素的渗透选择性较差|且该金属配位印迹聚合物膜对不同阳离子和阴离子也都表现出较好的选择识别作用.

关键词: 金属配位印迹聚合物膜, 膜渗透, 槲皮素, Zn(II)

Using Zn(II)-Quercetin complex as template (Quercetin is a kind of flavonoids which are important active ingredients of Chinese herbs.), 4-vinylpyridine as the functional monomer, ethylene glycol dimethacrylate (EDMA) as the crosslinker and linear water-soluble polymer polyethylene glycol (PEG Mw＝600) as the additive, Zn(II)-Quercetin metal-complexing imprinted polymer membrane with supporting structure were prepared through in-situ polymerization by UV irradiation. The surface morphologies of metal-complexing imprinted polymer membranes with different PEG dosage were determined by the scanning electron microscopy (SEM). The effects of additive PEG on the infiltration rate and permeation selectivity of the imprinted polymer membranes were investigated systematically. The experimental results indicated that the addition of the linear water-soluble polymer PEG could significantly improve the permeation properties of the imprinted polymer membrane, and compared with Quercetin s structural analogs (Rutin and Naringenin), the Zn(II)-Quercetin imprinted polymer membrane exhibited significant permeation selectivity for Quercetin, including selectivities to the anions and cations.

Key words: metal-complexing polymer membrane, membrane permeation, Quercetin, Zn(II)