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化学学报
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化学学报 ›› 2011, Vol. 69 ›› Issue (08): 1024-1028. 上一篇    

研究简报

一种新型铜离子荧光分子探针的合成与性能研究

易卫国1,2，张荣2，顾峥2，李珺姊2，邓琴2，向建南*,1,2   

  1. (1湖南化工职业技术学院 株洲 412004)
    (2湖南大学化学化工学院 化学传感与计量学国家重点实验室生物医学工程中心 长沙 410082)
  • 投稿日期:2010-06-30 修回日期:2010-10-22 发布日期:2010-11-15
  • 通讯作者: 向建南 E-mail:jnxiang@hnu.cn
  • 基金资助:

    863计划重点子项;湖南省科技计划项目

Synthesis and Characterization of a New Fluorescence Molecular Probe for Copper Ions

Yi Weiguo1,2 Zhang Rong2 Gu Zheng2 Li Junzi2 Deng Qin2 Xiang Jiannan*,1,2   

  1. (1 Hunan Chemical Industry Vocation Technology Institute, Zhuzhou 412004)
    (2 Biomedical Engineering Center and State Key Laboratory of Chemo/biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082)
  • Received:2010-06-30 Revised:2010-10-22 Published:2010-11-15
  • Contact: XIANG Jian-Nan E-mail:jnxiang@hnu.cn

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2059

被引次数

20

设计合成了一种新型的以二苯乙烯为荧光团、双(2-吡啶甲基)胺(DPA)为识别基团的铜离子荧光分子探针(E)-4-(4-(双吡啶甲基胺)苯乙烯基)氰基苯(1), 其结构用UV, IR, 1H NMR, 13C NMR和GC/MS进行了表征, 并考察了其荧光性能. 结果表明该荧光分子探针在CH3CN/H2O (1/9, V/V)溶液中, 能从众多常见的金属离子中以96.45%的荧光淬灭率选择性地识别铜离子, 对Cu2＋响应的线性工作范围在0.01～0.50 μmol/L之间, 且检测下限达25 nmol/L.

关键词: 荧光分子探针, 铜离子, 双(2-吡啶甲基)胺, 二苯乙烯

In this paper, a novel fluorescence molecular probe for copper ions that utilizes stilbene as a recognizing group and bis-2-picolylamine as a ionophore was designed and synthesized. The compounds were identified by UV-visible spectrum, IR spectrum, 1H NMR, 13C NMR and GC/MS etc., and the fluorescence properties of the molecular probe was investigated. The new fluorescence molecular probe exhibited excellent selectivity for copper ions among many common metal ions in CH3CN/H2O (1∶9, V∶V) solution, that the fluorenscence quenching ratio is 96.45%, with a linear working range of 0.01～0.50 μmol/L and a detection limit of 25 nmol/L Cu2＋.

Key words: fluorescence molecular probe, copper ions, di-2-picolylamine, stilbene

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