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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (22): 2513-2517. 上一篇    下一篇

研究论文

藤黄化学成分的研究

贾明美a 寿清耀a 谭 青a 沈征武*,a,b

  

  1. (a上海中医药大学中药学院 上海 201203)
    (b巴塞利亚药业(中国)有限公司 海门 226100)

  • 投稿日期:2008-04-11 修回日期:2008-07-03 发布日期:2008-11-28
  • 通讯作者: 沈征武

Chemical Constitutes of Garcinia hanburyi

JIA, Ming-Mei a SHOU, Qing-Yao a TAN, Qing a SHEN, Zheng-Wu *,a,b   

  1. (a School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203)
    (b Basilea Pharmaceutica China Ltd., Haimen, Jiangsu 226100)
  • Received:2008-04-11 Revised:2008-07-03 Published:2008-11-28
  • Contact: SHEN, Zheng-Wu

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传统中药藤黄通过各种色谱方法分离纯化, 得到15个化合物, 根据其理化性质和光谱方法鉴定其结构分别为: 2α-羟基-3β-乙酰氧基白桦酯酸(1), 10α-羟基表藤黄酸(2), 藤黄酸(3), 异藤黄酸(4), gambogin (5), gambogoic acid B (6), desoxymorellin (7), isomorellin (8), gambogenic acid (9), isogambogenin (10), gambogellic acid (11), desoxygambogenin (12), morellic acid (13), isomorellic acid (14), 30-hydroxygambogic acid (15). 其中化合物1和2为新化合物.

关键词: 藤黄, 藤黄科, 桥环xanthone, 五环三萜酸, 白桦酯酸

Fifteen compounds were isolated from Garcinia hanburyi., and identified as 2α-hydroxy-3β- acetoxy-lup-20(29)-en-28-oic acid (1), 10α-hydroxyepigambogic acid (2), gambogic acid (3), isogambogic acid (4), gambogin (5), gambogoic acid B (6), desoxymorellin (7), isomorellin (8), gambogenic acid (9), isogambogenin (10), gambogellic acid (11), desoxygambogenin (12), morellic acid (13), isomorellic acid (14), and 30-hydroxygambogic acid (15). 1 and 2 are new compounds.

Key words: Garcinia hanburyi, guttiferae, caged xanthone, pentacyclic triterpenoid, betulinic acid