化学学报 ›› 1989, Vol. 47 ›› Issue (9): 884-889. 上一篇    下一篇

研究论文

Vobasine-Aspidosperma型双吲哚生物碱的半合成

黄知恒;郑皎皎;周韵丽   

  1. 中国科学院上海药物研究所
  • 发布日期:1989-09-15

Partial synthesis of vobasine-aspidosperma type bisindole alkaloids

HUANG ZHIHENG;ZHENG JIAOJIAO;ZHOU YUNLI   

  • Published:1989-09-15

Aspidosperma型生物碱与Vobasinol在酸性介质中偶合, 得到四个双吲哚生物碱,用^1HNMR与高分辨质谱推定了它们的结构, 各产物对肿瘤细胞生长有显著的抑制作用。

关键词: 抗癌药, 质谱法, 吲哚生物碱, 质子磁共振谱法, 合成法

Four vobasine-aspidosperma type bisindole alkaloids were prepared by coupling the monomeric counterparts in acidic medium and their structure confirmed by 1H NMR and MS. These new alkaloids, in particular I, showed remarkable antitumor activity to suppress the growth of P-388 cells in vitro.

Key words: ANTICARCINOGEN, MASS SPECTROGRAPHY, INDOLE ALKALOIDS, PROTON MAGNETIC RESONANCE SPECTROMETRY, SYNTHESIS METHODS

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