化学学报 ›› 2003, Vol. 61 ›› Issue (7): 1058-1064. 上一篇    下一篇

研究论文

秦岭苦参中苦参碱立体异构体晶体结构研究

张尊听;杨伯伦;刘廉光;郁开北   

  1. 陕西师范大学化学与材料科学学院,西安(710062);西安交通大学环境与化学 工程学院,西安(710069);中国科学院成都分院分析测试中心,成都(610041)
  • 发布日期:2003-07-15

Crystal Structure of Steoreiosomers of Matrine from Sophora flavescens in the Qin Mountain

Zhang Zunting;Yang Bolun;Liu Qianguang;Yu Kaibei   

  1. College of Chemistry and Materials Science, Shaanxi Normal Normal University,Xi'an(710062);College of Environment and Chemical Engineering, Xi'an Jiaotong University,Xi'an(710069);Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences,Chengdu (610041)
  • Published:2003-07-15

从秦岭地区苦参中经过溶剂提取和酸化分离得到一种生物碱盐酸盐结晶1,该 晶体不对称单元含有一对新的苦参碱非对映异构体,绝对构型分别是1S,5S6S, 7R,11R,16S和1S,5S,6S,7R,11R,16R,命名为顺式新苦参碱(cis- neomatrine)和反式新苦参碱(trans-neomatrine)。1的晶体结构(C_(15)H_(24) N_2O·C_(15)H_(24)N_2O·2HCl·5H_2O)属正交晶系,空间群P2_12_12_1, a = 0. 8053(2) nm, b = 1.3464(5) nm, c = 3.0971(9) nm, V = 3.3580(18)nm~3, Z = 4, μ=0.244 mm~(-1), F(000) = 1432, R = 0.0467, wR = 0.1129。顺式新苦参 碱和反式新苦参碱的A环、B环和C环为式构象,D环为半椅式构象,其中A/B为反式 稠合,A/C和B/C为顺式稠合,两种立异构体的区别是顺式新苦参碱的C/D顺式稠 合,反式新苦参碱的C/D反式稠合。

关键词: 苦参碱, 晶体结构, 构象, 异构体

Key words: MATRINE, CRYSTAL STRUCTURE, CONFORMATION, ISOMER

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