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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (14): 1399-1402. 上一篇    下一篇

研究简报

穿心莲中两个黄酮苷的波谱学研究

任秀华*,1, 杜光1, 周冰峰2, 宗凯1, 马宝瑕1   

  1. (1华中科技大学同济医学院附属同济医院药学部 武汉 430030)
    (2浙江京新药业股份有限公司 新昌 310000)
  • 投稿日期:2006-11-01 修回日期:2007-02-07 发布日期:2007-07-28
  • 通讯作者: 任秀华

Study on the Spectroscopy of Two Flavonyl Glycosides from Andrographis paniculata

REN Xiu-Hua*,1; DU Guang1; ZHOU Bing-Feng2; ZONG Kai1; MA Bao-Xia1   

  1. (1 Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030)
    (2 Zhejiang Jingxin Pharmaceutical Co., Ltd., Xinchang 310000)
  • Received:2006-11-01 Revised:2007-02-07 Published:2007-07-28
  • Contact: REN Xiu-Hua

PDF

779

被引次数

12

研究了穿心莲中抗血栓的活性成分. 应用AB-8大孔吸附树脂、聚酰胺柱色谱及薄层色谱进行分离, 应用波谱学(1H NMR, 13C NMR, DQFCOSY, TOCSY, HMQC, HMBC, NOESY等)方法进行结构鉴定. 分离得到两个黄酮苷类化合物, 确定了1H NMR, 13C NMR信号的全归属. 化合物1鉴定为5,4'-二羟基-7-甲氧基黄酮-6-O-β-D-葡萄糖苷, 化合物2鉴定为5,4'-二羟基-7-甲氧基黄酮-8-O-β-D-葡萄糖苷, 化合物1为首次从该植物中分得, 首次对两个化合物的碳谱和氢谱进行了全归属.

关键词: 穿心莲, 5,4'-二羟基-7-甲氧基黄酮-6-O-β-D-葡萄糖苷, 5,4'-二羟基-7-甲氧基黄酮-8-O-β-D-葡萄糖苷, 核磁共振, 结构分析

To study the bioactive constituents from Andrographis paniculata, two compounds were isolated and purified by column chromatography on AB-8 macroporous adsorption resin and polyamide. The structures were determined by various spectroscopic data, including UV, FABMS, 1H NMR, 13C NMR, DQFCOSY, TOCSY, HMQC, HMBC and NOESY. The 1H NMR and 13C NMR signals of these two compounds were assigned. The structures of these two compounds were elucidated as 5,4'-dihydroxy-7-methoxyflavon-6-yl-β-D-pyranoglucoside and 5,4'-dihydroxy-7-methoxyflavon-8-yl-β-D-pyranoglucoside, res- pectively.

Key words: Andrographis paniculata, 5,4'-dihydroxy-7-methoxyflavon-6-yl-β-D-pyranoglucoside, 5,4'-dihydroxy-7-methoxyflavon-8-yl-β-D-pyranoglucoside, NMR, structure analysis