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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (16): 1654-1656. 上一篇    下一篇

研究论文

四氢噻唑-2-硫酮用于赖氨酸侧链选择性保护反应

高兴明, 叶蕴华*   

  1. (北京大学化学与分子工程学院 教育部生物有机化学与分子工程重点实验室 北京 100871)
  • 投稿日期:2007-03-28 修回日期:2007-06-20 发布日期:2007-08-28
  • 通讯作者: 叶蕴华

Application of Tetrahydrothiazole-2-thione (TTT) in the Reaction of Selective Side Chain Protection of Lysine

GAO Xing-Ming; YE Yun-Hua*   

  1. (The Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871)
  • Received:2007-03-28 Revised:2007-06-20 Published:2007-08-28
  • Contact: YE Yun-Hua

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888

被引次数

5

用四氢噻唑-2-硫酮(TTT)分解赖氨酸-铜配合物,合成侧链氨基被选择性保护的赖氨酸衍生物Na-Boc-Ne-Fmoc-L-Lys-OH. 研究结果表明四氢噻唑-2-硫酮分解氨基酸铜配合物比传统试剂(H2S, EDTA, HCl)速度快, 反应彻底, 且副产物易除去.

关键词: 四氢噻唑-2-硫酮(TTT), 赖氨酸衍生物, 氨基酸-铜配合物

A lysine derivative with selectively protected side chain Na-Boc-Ne-Fmoc-L-Lys-OH was synthesized through decomposition of lysine cupric complex with tetrahydrothiazole-2-thione (TTT). The results indicate that the decomposition is faster and more complete, the by-product was easier to be removed than that with traditional reagents (H2S, EDTA, HCl).

Key words: tetrahydrothiazole-2-thione (TTT), lysine derivative, amino acid-cupric complex