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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (18): 2051-2056. 上一篇    下一篇

研究论文

表面图案化磁性复合微球的原位制备与表征

王公正*,1,2, 夏慧芸1, 张颖1, 彭世杰1   

  1. (1陕西师范大学化学与材料科学学院应用表面与胶体化学教育部重点实验室 西安 710062)
    (2陕西师范大学物理学与信息技术学院 西安 710062)
  • 投稿日期:2007-01-22 修回日期:2007-05-08 发布日期:2007-09-28
  • 通讯作者: 王公正

Magnetic Composite Microspheres with Patterned Surface Structures: Preparation in situ and Characterization

WANG Gong-Zheng*,1,2; XIA Hui-Yun1; ZHANG Ying1; PENG Shi-Jie1   

  1. (1 Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062)
    (2 School of Physics & Information Technology, Shaanxi Normal University, Xi'an 710062)
  • Received:2007-01-22 Revised:2007-05-08 Published:2007-09-28
  • Contact: WANG Gong-Zheng

PDF

1043

被引次数

47

采用反相悬浮聚合法合成了丙烯酸(AA)含量不同的N-异丙基丙烯酰胺-丙烯酸共聚物P(NIPAM-co-AA)微凝胶, 并以其作为微反应器, 通过原位外源沉积法制备了一系列微米级、表面具有图案化结构的SiO2-Fe3O4-P(NIPAM-co-AA)磁性复合微球. 实验结果表明, 复合微球的表面结构与微凝胶的组成、Fe3O4和SiO2的沉积量有关. 在微球表面进行修饰, 可得到表面带有氨基等官能基团的磁性复合材料. 将这种功能化磁性微球用于识别生物大分子并进一步用于生物医学领域具有重要的意义.

关键词: 反相悬浮聚合法, 微凝胶模板, 磁性复合微球, 磁滞回线偏移

N-isopropylacrylamide (NIPAM) and acrylic acid (AA) copolymer microspheres with various compositions were prepared by a reverse suspension polymerization technique. The microspheres thus prepared were employed as micro-reactors for the synthesis of Fe3O4 and the deposition of SiO2 in situ. In this way, several kinds of SiO2-Fe3O4-P(NIPAM-co-AA) magnetic composite microspheres with different surface morphologies were prepared. It was demonstrated that the surface structures of the composite microspheres could be tailored to a certain extent by varying the ratio of the two monomer units in the template (microgels), the amount of Fe3O4 adsorbed and the amount of SiO2 deposited. The magnetic composite microsphere surface was modified by the NH2 groups via silanization reagent (3-aminopropyltrimethoxysi- lane). It might be expected that this functional material can be applied for recognition of biomacromolecules and in biological medical fields.

Key words: reverse suspension polymerization, microgel template, magnetic composite microsphere, shift of magnetic hysteresis loop