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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (18): 2029-2033. 上一篇    下一篇

研究论文

Mn2＋-NaY型分子筛作为口服胃肠道MRI造影剂的研究

李伟生1, 李中峰1, 景凤英1, 杨向光1, 李晓晶*,1, 裴奉奎*,1, 王旭霞2, 雷皓2   

  1. (1中国科学院长春应用化学研究所 国家电化学和光谱研究分析中心 绿色化学与过程实验室 长春130022)
    (2中国科学院武汉物理与数学研究所 波谱与原子分子物理国家重点实验室 武汉 430071)
  • 投稿日期:2007-01-29 修回日期:2007-04-29 发布日期:2007-09-28
  • 通讯作者: 李晓晶, 裴奉奎

Zeolites Mn2＋-NaY as Oral Gastrointestinal Tract Contrast Agents in Magnetic Resonance Imaging

LI Wei-Sheng1; LI Zhong-Feng1; JING Feng-Ying1; YANG Xiang-Guang1; LI Xiao-Jing*,1; PEI Feng-Kui*,1; WANG Xu-Xia2; LEI Hao2   

  1. (1 National Research and Analysis Center of Electrochemistry and Spectroscopy, Green Chemistry and Process Laboratory, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022)
    (2 Laboratory of Resonance & Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071)
  • Received:2007-01-29 Revised:2007-04-29 Published:2007-09-28
  • Contact: LI Xiao-Jing; PEI Feng-Kui

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用离子交换法制备了Mn2＋交换的NaY分子筛MnNaY, 用红外光谱(IR)和X射线粉末衍射(XRD)等方法进行了表征. 研究了Mn2＋含量为3.2%的样品在酸性水溶液中的稳定性和离子交换选择性. 弛豫时间测量和体内磁共振成像实验表明其弛豫效率变化范围为4.9～9.7 mmol•L•s－1, 高于目前临床所用造影剂Gd-DTPA, 对胃部MRI信号具有良好的增强效果. 它是比较好的潜在口服胃肠道造影剂.

关键词: 磁共振成像, NaY分子筛, 造影剂, 弛豫效率, 锰(II)

Mn2＋-loaded zeolites were prepared by ion-exchange of NaY with MnCl2 and characterized by IR and XRD. The stability of MnNaY (3.2% Mn) at low pH and in the presence of metal ions at a concentration relevant to the gastrointestinal tract has been evaluated. The T1-relaxivities of MnNaY decreased as the Mn2＋ loading increased from 3.2% to 5.2%, with values ranging between 4.9 and 9.7 mmol•L•s－1 at 400 MHz and 23 ℃. T1-weighted magnetic resonance imaging (MRI) of rats’ abdomen showed a remarkable enhancement after oral administration of MnNaY (3.2% Mn). The results indicate that the MnNaY may be a potential gastrointestinal tract contrast agent for MRI.

Key words: magnetic resonance imaging, NaY zeolite, contrast agent, relaxivity, manganese(II)