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化学学报
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化学学报 ›› 2009, Vol. 67 ›› Issue (16): 1903-1909. 上一篇    下一篇

研究论文

末端带有磷酰胆碱基团的聚丁二酸丁二醇酯的合成、表征和性能研究

张世平 朱霞霞 宫永宽*

  

  1. (西北大学化学与材料科学学院 合成与天然功能分子化学教育部重点实验室 西安 710069)

  • 投稿日期:2009-01-11 修回日期:2009-03-16 发布日期:2009-08-28
  • 通讯作者: 宫永宽

Synthesis, Characterization and Properties of Phosphorylcholine Functionalized Poly(butylene succinate)

Zhang, Shiping Zhu, Xiaxia Gong, Yongkuan*   

  1. (Key Laboratory of Synthetic and Natural Functional Molecule Chemistry (Ministry of Education), College of Chemistry & Materials Science, Northwest University, Xi’an 710069)
  • Received:2009-01-11 Revised:2009-03-16 Published:2009-08-28
  • Contact: Gong, Yongkuan

PDF

1458

被引次数

11

采用四步反应合成了一种新的具有良好生物相容性和生物降解性的末端带有磷酰胆碱(PC)基团的聚丁二酸丁二醇酯PBS-PC. 采用1H NMR、IR、凝胶色谱(GPC)和X射线光电子能谱(XPS)表征了聚合物的结构. 同时研究了聚合物的亲疏水性能、体外降解、溶胀率和对模型药物中性红的缓释性能. 结果显示: PC基团引入, 在一定程度上提高了PBS的亲水性、降解速率、溶胀率和对中性红的缓释性能.

关键词: 聚丁二酸丁二醇酯, 磷酰胆碱, 体外降解, 溶胀, 中性红, 药物控释

A new biodegradable and biocompatible polymer, phosphorylcholine functionalized poly(butylene succinate) (PBS-PC) was synthesized via a four-step synthetic strategy. The results of 1H NMR, IR, gel permeation chromatography (GPC) and X-ray photoelectron spectroscopy (XPS) measurements demonstrated a successful construction of PBS-PC. Dynamic contact angle, in vitro degradation, swelling behavior and drug release measurements revealed that the PBS-PC showed higher hydrophilicity, degradation, swelling and faster drug release rates by using neutral red as a model drug.

Key words: poly(butylene succinate), phosphorylcholine, in vitro degradation, swelling behavior, neutral red, drug release