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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (24): 2952-2958. 上一篇    下一篇

研究论文

海藻酸钙-壳聚糖微胶囊组成对BSA通透性能影响的研究

邢楠, 田丰*, 刘圣军, 杨健, 陈世谦, 赵永亮   

  1. (军事医学科学院卫生装备研究所 天津 300161)
  • 投稿日期:2007-01-10 修回日期:2007-06-01 发布日期:2007-12-28
  • 通讯作者: 田丰

Study on the Effect of Composition of Calcium Alginate-Chitosan Microcapsule on BSA Permeability

XING Nan; TIAN Feng*; LIU Sheng-Jun; YANG Jian; CHEN Shi-Qian; ZHAO Yong-Liang   

  1. (Institute of Medical Equipment, Academy of Military Medical Sciences, Tianjin 300161)
  • Received:2007-01-10 Revised:2007-06-01 Published:2007-12-28
  • Contact: TIAN Feng

PDF

2476

被引次数

32

对海藻酸钙-壳聚糖微胶囊的牛血清白蛋白(BSA)双向通透性能进行了定量和定性的初步研究, 并初步考察了微胶囊的组成成分及海藻酸钠、壳聚糖的溶液浓度对BSA通透性能的影响. 结果表明海藻酸钙-壳聚糖微胶囊在pH 1.5～2.0时通透性减弱, pH 6.8时通透性增强, 且海藻酸钙微胶囊通透性大于海藻酸钙-壳聚糖微胶囊; 海藻酸钙-壳聚糖微胶囊中壳聚糖浓度越小, 通透性越好; 海藻酸钠浓度的影响不显著.

关键词: 海藻酸钙-壳聚糖, 微胶囊, 牛血清白蛋白(BSA), 双向, 通透性

Bovine serum albumin (BSA) bidirectional permeability of calcium alginate-chitosan microcapsules was investigated by quantitative and qualitative researches. The effects of composition of the microcapsules and concentrations of alginate and chitosan were studied. The results show that BSA permeability of the microcapsules decreases when pH is 1.5 to 2.0, whereas increases when pH is 6.8. Permeability of the calcium alginate microcapsules is better than that of the calcium alginate-chitosan microcapsules, and for the calcium alginate-chitosan microcapsules the lower the concentration of chitosan is, the higher the permeability is. The effect of concentration of alginate is not obvious.

Key words: calcium alginate-chitosan, microcapsule, bovine serum albumin (BSA), bidirectional, permeability