化学学报 ›› 1991, Vol. 49 ›› Issue (2): 183-186. 上一篇    下一篇

研究论文

青蒿素及其衍生物的圆二色谱研究

沈春镒;李英   

  1. 中国科学院上海药物研究所
  • 发布日期:1991-02-15

Circular dichroism study of qinghaosu and its derivatives

SHEN CHUNYI;LI YING   

  • Published:1991-02-15

本文通过对青蒿素及其16个衍生物的圆二色谱研究, 首交次确定了青蒿素衍衍生物8、9和17的过氧键的圆二色谱的λ~max和它的△s值。并对青蒿素衍生物的圆二色谱出现类似旋光谱中的“背景曲线”的异常现象作了探讨。

关键词: 衍生物, 圆振二向色性, 青蒿素

The CD spectra of Qinghaosu and its sixteen derivatives were studied and the Cotton effects of the peroxide chromophore in compound I (R = COCH:CH2), compound II, and compound I (R = COEt) were shown to be 231 (Dd = +0.63), 236 (Dd = +0.82) and 232 nm (Dd = +0.76).

Key words: DERIVATIVES, CIRCULAR DICHROISM, ARTEANNUIN

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