化学学报 ›› 1987, Vol. 45 ›› Issue (4): 403-407. 上一篇    下一篇

研究论文

酰氨基硫脲及有关的杂环衍生物的研究 I:1-氰乙酰基-4-芳基氨基硫脲及有关的杂环衍生物的合成

张自义;杨虎;高东哲   

  1. 兰州大学化学系;北京结核病院
  • 发布日期:1987-04-15

Studies on the acylthiosemicarbazides and related heterocyclic derivatives I: Synthesis of 1-cyanoacetyl-4-aryl-thiosemicarbazides and related heterocyclic derivatives

ZHANG ZIYI;YANG HU;GAO DONGZHE   

  • Published:1987-04-15

合成了九个1-氰乙酰基-4-芳基氨基硫脲类化合物和四个3-氰甲基-4-芳基-1,2,4-三唑啉与硫酮类化合物和四个2-苯基氨基-5-取代-1,3-噻二唑类化合物.并初步研究了这些化合物的抗结核菌活性和植物生长促进作用.

关键词: 硫酮, 氮杂环化合物, 植物生长调节剂, 噻二唑 P, 三唑 P, 硫氰酸酯, 氰乙酸 P, 氨基硫脲 P, 酰肼 P

Refluxing NCCH2CONHNH2 with RNCS (R = Ph, 4-MeOC6H4, 4-ClC6H4, 3-BrC6H4, 4-MeC6H4, 1-naphthyl, 2-naphthyl, 4-BrC6H4, 3,4-Me2C6H3) in EtOH gave NCCH2CONHNHC(S)NHR (I). Cyclization of I (R = Ph, 4-MeOC6H4, 4-MeC6H4, 3,4-Me2C6H2) with aqueous K2CO3 gave triazolinethiones II, whereas cyclization of I (R = Ph) with concentrated H2SO4 gave thiadiazoles III (R1 = NCCH2, H2NCOCH2).

Key words: THIOKETONE, NITROGEN HETEROCYCLICS, PLANT GROWTH REGULATORS, THIADIAZOLE P, PYRRODIAZOLE P, THIOCYANIC ACID ESTER, CYANOACETIC ACID P, THIOSEMICARBAZIDE P, HYDRAZIDE P

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