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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (3): 222-226. 上一篇    下一篇

研究论文

主客体包结法选择分离白花前胡的化学成分

佟健1, 王忠华1, 徐赫男2,3, 袁雷3, 郭放1, 常键4, 刘成雁4, 郭文生*,1   

  1. (1辽宁大学化学科学与工程学院 沈阳 110036)
    (2郑州大学化学系 郑州 450052)
    (3沈阳药科大学制药工程学院 沈阳 110015)
    (4辽宁省分析测试研究院 沈阳 110015)
  • 投稿日期:2006-04-25 修回日期:2006-08-22 发布日期:2007-02-14
  • 通讯作者: 郭文生

Selective Isolation of Component of Baihuaqianhu Using Inclusion Crystalline of Host and Guest

TONG Jian1; WANG Zhong-Hua1; XU He-Nan2,3; YUAN Lei3; GUO Fang1; CHANG Jian4; LIU Cheng-Yan4; GUO Wen-Sheng*,1   

  1. (1 Institute of Chemical Science & Engineering, Liaoning University, Shenyang 110036)
    (2 Department of Chemistry, Zhengzhou University, Zhengzhou 450052)
    (3 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110015)
    (4 Liaoning Provincial Institute of Analysis Testing and Research, Shenyang 110015)
  • Received:2006-04-25 Revised:2006-08-22 Published:2007-02-14
  • Contact: GUO Wen-Sheng

PDF

1025

被引次数

16

以1,1,6,6-四苯基-2,4-己二炔-1,6-二醇为主体分子, 可简单、迅速地从白花前胡粗提物中选择分离有效成分3'-乙酰氧基-4'-β-羟基丙酰氧基-3',4'-二氢邪蒿内酯, 收率为0.17%. IR, 1H NMR, 13C NMR光谱和单晶衍射证实了包结化合物的形成及其晶体结构, 并且用气相色谱方法(GC)评价了选择分离效果.

关键词: 白花前胡, 包结化合物, 选择分离, 3'-乙酰氧基-4'-β-羟基丙酰氧基-3',4'-二氢邪蒿内酯

3'-Acetoxy-4'-β-hydroxyl-propyloxy-3',4'-dihydroseselin can be selectively isolated from the crude of BAIHUAQIANHU simply and rapidly using 1,1,6,6-tetraphenylhexa-2,4-diyne-1,6-diol as host with yield of 0.17%. Inclusion compound crystal structure was confirmed by IR, 1H NMR, 13C NMR spectra and single crystal X-ray diffraction analysis. GC method was used to assess the isolation effect.

Key words: baihuaqianhu, inclusion compound, selective isolation, 3'-acetoxy-4'-β-hydroxyl-propyloxy- 3'4'-dihydroseselin