化学学报 ›› 1983, Vol. 41 ›› Issue (7): 659-662. 上一篇    下一篇

研究论文

顺反构型[Rh(NH3)3Cl]在室温水溶液中的行为兼论铂配合物的抗癌机理及药效

陈梅芳;江敦闻   

  1. 冶金工业部贵金属研究所
  • 发布日期:1983-07-15

The behaviour of mer-(RH(NH3)3Cl3) and fac-(RH(NH3)3Cl3) in aqueous solution at room temperature -- a preliminary discussion on the mechanism of action of anti-tumour platinum compounds

CHEN MEIFANG;JIANG DUNWEN   

  • Published:1983-07-15

关键词: 抗癌药, 氯络合物, 氨络合物, 钕络合物, 铂系金属络合物

In this paper the behaviour of mer-and fac-(Rh(NH3)3Cl3) in aqueous solution at room temperature is reported. The experimental results show that some obvious differences exist between the properties of mer-and fac-(Rh(NH3)3Cl3) coordination compounds in aqueous solution at room temperature. The fac-(Rh(NH3)3Cl3) is relatively stable, and the mer-(Rh(NH3)3 Cl3) is unstable. When one of its Cl^- is replaced by H2O(RH(NH3)3)(OH)2Cl2)Cl is formed. The mechanism of anti-tumour action of platinum compounds is briefly discussed.

Key words: ANTICARCINOGEN, CHLORO COMPLEX, AMMINE COMPLEX, NEODYMIUM COMPLEX, PLATINUM METAL COMPLEX

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