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化学学报
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化学学报 ›› 2005, Vol. 63 ›› Issue (9): 869-872. 上一篇    

研究简报

地奥心血康中的两个新甾体皂苷

陈洪超，付铁军，刘忠荣，廖循，丁立生*   

  1. (中国科学院成都生物研究所国家天然药物工程技术研究中心 成都 610041)
  • 投稿日期:2004-09-17 修回日期:2005-01-04 发布日期:2010-12-10
  • 通讯作者: 丁立生

Two New Steroidal Saponins from Di'aoxinxuekang

CHEN Hong-Chao, FU Tie-Jun, LIU Zhong-Rong, LIAO Xun, DING Li-Sheng*   

  1. (National Engineering and Research Center for Natural Medicines, Chengdu Institute of Biology,
    Chinese Academy of Sciences, Chengdu 610041)
  • Received:2004-09-17 Revised:2005-01-04 Published:2010-12-10
  • Contact: DING Li-Sheng

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1446

被引次数

51

通过正相和反相硅胶柱层析, 从地奥心血康药粉的正丁醇萃取物中分离纯化出2个微量的新甾体皂苷, 通过MS和NMR(包括HMQC, HMBC和NOESY)等波谱解析, 结合化学降解分析将其结构鉴定为3β,26-二醇-25(R)-Δ5,20(22)-二烯-呋甾-26-O-β-D-吡喃葡萄糖苷(1)和26-O-β-D-吡喃葡萄糖基-3β,20α,26-三醇-25(R)-Δ5,22-二烯-呋甾-3-O-α-L-吡喃鼠李糖基(1→2)-[α-L-吡喃鼠李糖基(1→4)]-β-D-吡喃葡萄糖苷(2).

关键词: 地奥心血康, 黄山药, 穿龙薯蓣, 甾体皂苷

Two new furostanol-type steroidal saponins were isolated from Di'aoxinxuekang, the total saponin from the roots of Dioscorea panthaica and D. nipponica. On the basis of spectroscopic and chemical evidence, their structures were elucidated as 3β,26-diol-25(R)-Δ5,20(22)-dienofurostan-26-O-β-D-glucopyranoside (1) and 26-O-β-D-glucopyranosyl-3β,20α,26-triol-25(R)-Δ5,22-dienofurostan-3-O-α-L-rhamnopyranosyl(1→2)-[α-L-rhamnopyranosyl(1→4)]-β-D-glucopyranoside (2).

Key words: Di'aoxinxuekang, Dioscorea panthaica, Dioscorea nipponica, steroidal saponin