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化学学报
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化学学报 ›› 2007, Vol. 65 ›› Issue (8): 693-698. 上一篇    下一篇

研究论文

用胶束液相色谱模拟生物膜预测药物的醇-水分配系数log P

贾宏瑛1, 杨更亮*,1,2, 辛培勇1, 陈义1   

  1. (1中国科学院化学研究所 北京 100080)
    (2河北大学药学院 保定 071002)
  • 投稿日期:2006-09-26 修回日期:2006-12-01 发布日期:2007-04-28
  • 通讯作者: 杨更亮

Prediction of Octanol-Water Partition Coefficients (log P) of Drugs by Micellar Liquid Chromatography Simulating Biomembrane

JIA Hong-Ying1; YANG Geng-Liang*,1,2; XIN Pei-Yong1; CHEN Yi1   

  1. (1 Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080)
    (2 College of Pharmacy, Hebei University, Baoding 071002)
  • Received:2006-09-26 Revised:2006-12-01 Published:2007-04-28
  • Contact: YANG Geng-Liang

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通过比较药物在不同类型表面活性剂的胶束液相色谱中的容量因子与药物的醇-水分配系数(log P)的相关性, 发现药物在非离子型表面活性剂Brij35作为流动相的胶束液相色谱中的容量因子与其文献中报道的log P间有一定的相关性, 进一步考察了Brij35浓度对药物保留的影响, 并建立了药物在不同浓度的Brij35胶束液相色谱中的容量因子与文献中log P的相关关系, 该方法简单、快速, 将为药物的疏水性评价提供重要的参考价值.

关键词: 胶束液相色谱, Brij35表面活性剂, 醇-水分配系数log P

Brij35 micellar liquid chromatography (MLC) was presented for prediction of the octanol-water partition coefficient (log P) of drugs by comparing the retention factors of drugs in different surfactants with log P in literature. The results showed that the retention factors of drugs in Brij35 MLC were related with log P of drugs in literature. The effect of Brij35 concentration on the retention of drugs was studied and the relationship was established between the retention factors of drugs in surfactant of different concentration and log P. This method is simple, rapid and can provide valuable reference information for hydrophobicity of drugs.

Key words: micellar liquid chromatography, surfactant Brij35, octanol-water partition coefficient log P