化学学报 ›› 1998, Vol. 56 ›› Issue (7): 707-713. 上一篇    下一篇

研究论文

新型血管紧张素转化酶抑制剂: 氮杂三肽类似物的合成及结构活性关系

刘世峰;徐杰诚   

  1. 中国科学院上海有机化学研究所
  • 发布日期:1998-07-15

Novel angiotensin converting enzyme inhibitors: Synthesis and structure-activity relationship of azatripeptide analogs

LIU SHIFENG;XU JIECHENG   

  • Published:1998-07-15

设计与合成一系列氮杂三肽类似物, 测定了氮杂三肽类似物对血管紧张素转化酶的体外抑制活性, 探讨了它们的结构与抑制活性之间的关系, 结果表明氮杂丙氨酸是丙氨酸很好的替代物。

关键词: 紫外分光光度法, 降压药, 元素分析, 质子磁共振谱法, 血管紧张素转化酶, 氮杂三肽类似物

A series of azatripeptide analogs were designed and synthesized. The in vitro inhibitory activities of these compounds toward angiotensin converting enzyme (ACE) were evaluated. Furthermore, the structure-activity relationship of these compound was discussed. The results showed that azaalanine was a good isosterer of alanine in angiotensin converting enzyme inhibitors.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, ANTIHYPERTENSIVE AGENTS, ELEMENTAL ANALYSIS, PROTON MAGNETIC RESONANCE SPECTROMETRY

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