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化学学报
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化学学报 ›› 2006, Vol. 64 ›› Issue (8): 806-810. 上一篇    下一篇

研究论文

柔红霉素修饰的纳米金电极的制备及其对DNA检测

郑华，胡劲波*，李启隆   

  1. (北京师范大学化学系 北京 100875)
  • 投稿日期:2005-07-01 修回日期:2005-12-26 发布日期:2006-04-25
  • 通讯作者: 胡劲波

Preparation of Daunomycin Modified Nano Gold Electrode and, Its Application to Detection of DNA

ZHENG Hua, HU Jing-Bo*, LI Qi-Long   

  1. (Department of Chemistry, Beijing Normal University, Beijing 100875)
  • Received:2005-07-01 Revised:2005-12-26 Published:2006-04-25
  • Contact: HU Jing-Bo

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1106

被引次数

54 | 6

利用双硫醇分子作为连接剂, 将纳米金颗粒固定于金电极上, 用伏安法、紫外-可见光谱和电化学交流阻抗对其组装过程以及活性进行了表征. 制备的纳米金修饰电极用于DNA测定及其对DNA损伤的检测. DNA的检测限为 1.2×10－9 mol/L. 该法灵敏、简便.

关键词: 纳米金, 柔红霉素, DNA

The modification of gold electrode with gold nanoparticles by chemical adsorption of 1,6-hexanedithiol was achieved. The preparation process and activity of this interface were characterized with voltammetry, UV-Vis spectroscopy and electrochemical impedance spectroscopy. The modified electrode was used to detect DNA and the damage of DNA, with the detection limit of DNA to be 1.2×10－9 mol/L. This method is sensitive and convenient.

Key words: gold nanoparticle, daunomycin, DNA