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化学学报
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化学学报 ›› 2005, Vol. 63 ›› Issue (22): 2077-2081. 上一篇    下一篇

研究论文

CaO-P2O5-SiO2系统溶胶-凝胶生物活性多孔材料在SBF中的性能研究

张晓凯*,1，陈晓峰2，王迎军2，张梅梅3   

  1. (1山东师范大学物理与电子科学学院 理化分析测试中心 济南 250014)
    (2华南理工大学材料学院生物材料研究所 广州 510640)
    (3山东轻工业学院材料科学与工程系 济南 250100)
  • 投稿日期:2005-03-23 修回日期:2005-08-29 发布日期:2010-12-10
  • 通讯作者: 张晓凯

Performance Investigation of the Sol-gel Porous Biomaterial ofthe System CaO-P2O5-SiO2 in SBF Solution

ZHANG Xiao-Kai*,1, CHEN Xiao-Feng2, WANG Ying-Jun2, ZHANG Mei-Mei3   

  1. (1 College of Physics and Electronics, Analysis and Testing Center, Shandong Normal University, Ji'nan 250014)
    (2 Institute of Biomaterials, College of Materials Science and Engineering,
    South China University of Technology, Guangzhou 510640)
    (3 Department of Materials Science and Engineering, Shandong Institute of Light Industry, Ji'nan 250100)
  • Received:2005-03-23 Revised:2005-08-29 Published:2010-12-10
  • Contact: ZHANG Xiao-Kai

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利用溶胶-凝胶生物活性材料粉末二次烧结工艺, 制备了CaO-P2O5-SiO2系统溶胶-凝胶生物活性多孔材料, 并利用体外实验(in vitro)方法和XRD, SEM及FTIR技术研究了此烧结材料的显微形貌、晶相、生物活性和可降解性能. 结果表明, 经800 ℃烧结5 min后, 有少量硅磷酸钙[Ca5(PO4)2SiO4, 5CPS]析出, 在模拟体液(SBF)中浸泡, 随着时间的增长, 材料表面最初形成的无定形钙磷化合物矿化成碳酸羟基磷灰石(HCA)纳米团簇, 并逐渐相互融合形成HCA覆盖层; HCA只在烧结体的玻璃相(SG相)表面生成, 在5CPS微晶相表面未发现HCA, 该材料在37 ℃恒温的SBF溶液中具有较高的生物活性和可降解性能.

关键词: 溶胶-凝胶技术, 生物活性, 模拟体液(SBF), 碳酸羟基磷灰石(HCA)

The porous bioactive material was prepared through secondary sintering of the sol-gel derived glass powder in the system CaO-P2O5-SiO2. The micro-morphologies, crystalline phases and bioactivity were investigated using in vitro test, XRD, SEM and FTIR techniques. It was indicated that a few Ca5(PO4)2SiO4 crystals (5CPS) were already formed in the porous material during sintering at 800 ℃ for 5 min. In the simulated body fluid (SBF), as the reaction progressed, the originally formed amorphous-phosphorus compound on the surface of glass were mineralized into hydroxy-carbonate-apatite (HCA) nanometer cluster, and interfused mutually until the HCA covering were formed. HCA crystallites were only formed on the glass phase, however not on the surface of 5CPS. This kind of material has the better bioactivity and biodegradability in SBF solution at the constant temperature 37 ℃.

Key words: sol-gel technology, bioactivity, simulated body fluid (SBF), hydroxyl-carbonate-apatite (HCA)