化学学报 ›› 2000, Vol. 58 ›› Issue (2): 135-143.    下一篇

研究论文

抗疟倍半萜过氧化物青蒿素和鹰爪素A的全合成

周维善;许杏祥   

  1. 中国科学院上海有机化学研究所.上海(200032)
  • 发布日期:2000-02-15

Total synthesis of the antimalarial sesquiterpene peroxide Qinghaosu and Yingzhaosu A

Zhou Weishan;Xu Xingxiang   

  1. Shanghai Inst Organ Chem., CAS.Shanghai(200032)
  • Published:2000-02-15

青蒿素和鹰爪素A是从中药中分离的两个含过氧基团的抗疟活性组分。特别是青蒿素已成为新型的抗疟药物,因而引起合成化学家的极大兴趣。现对该两个化合物的全合成作一综述。

关键词: 青蒿素, 鹰爪素, 倍半萜, 过氧化物, 单线态氧, 抗疟药, 全合成

Qinghaosu and Yingzhaosu are two peroxy-containing antimalarial constituents isolated from Chinese medicinal herbs. Qinghaosu has become a novel antimalarial drug and is interesting to synthetic organic chemists. This paper summarizes their total syntheses.

Key words: ARTEANNUIN, SESQUITERPENE, PEROXIDE, SINGLET OXYGEN, ANTIMALARIALS, TOTAL SYNTHESIS

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