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化学学报
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化学学报 ›› 1989, Vol. 47 ›› Issue (4): 328-332. 上一篇    下一篇

研究论文

具有生物活性的金属配合物的研究 III: 3-6(二(二甲氨基)-二苯并碘六环稀土二柠檬酸配合物的合成, 性质及抗肿瘤活性

陈淑英;王初华;侯自杰;李笃;刘力生;宋家玉   

  1. 兰州大学化学系;兰州大学生物系
  • 发布日期:1989-04-15

Study on biologically active coordination compounds of metal ions III: Synthesis, characterization and antitumor activity of rare earths citrate complexes of 3,6-bis(dimethylamino)-dibenzopyriodonium

CHEN SHUYING;WANG CHUHUA;HOU ZIJIE;LI DU;LIU LISHENG;SONG JIAYU   

  • Published:1989-04-15

PDF

596

被引次数

8

合成了十五种新的3,6-二(二甲氨基)-二苯并碘六环稀土二柠檬酸配合物, 其化学式为: [C17H20N2I]3[RE(C6H5O7)2].xH2O(RE=La-Nd, x=5; Sm-Tb, x=4; Dy-Lu, Y,x=3). 利用X射线粉末衍射、热重-差热, 红外光谱、紫外光谱、摩尔电导等对这些配合物进行了表征. 试验表明, 镧配合物对L7712癌细胞DNA合成的抑制率(97.3%)明显高于其前体(C17H20N2I^+.HCOO^-, 72.5%; Na3[La(C6H5O7)2], -16.5%.

关键词: 紫外分光光度法, 生物活性, 抗癌药, 红外分光光度法, Ｘ射线衍射分析, 苯 P, 柠檬酸, 稀土金属络合物, 铈络合物, 差热分析

L3[LnQ2].nH2O (L+ = 3,6-bis(dimethylamino)benzopyriodonium; H3Q = citric acid; Ln = La-Nd, n = 5; Ln = Sm-Tb, n = 4; Ln = Dy-Lu, Y, n = 3) were prepared The complexes were characterized by x-ray powder diffraction, TG-DTA, molar conductances, IR, UV and 1H NMR. Inhibiting effect of La complex on incorporation of 3H-TdR into DNA of leukemia (L7712) cells in vitro was observed The results show that La complex is more effective than its precursors.

Key words: ULTRAVIOLET SPECTROPHOTOMETRY, BIOLOGICAL ACTIVITY, ANTICARCINOGEN, INFRARED SPECTROPHOTOMETRY, X-RAY DIFFRACTION ANALYSIS, BENZENE P, CITRIC ACID, RARE EARTH METAL COMPLEX, CERIUM COMPLEX, DIFFERENTIAL THERMAL ANALYSIS

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