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化学学报
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化学学报 ›› 2008, Vol. 66 ›› Issue (10): 1269-1273. 上一篇    下一篇

研究论文

不同尺寸单分散PMMA/GMA/DVB聚合物荧光微球的制备

刘宏波，汪长春*   

  1. (聚合物分子工程教育部重点实验室 复旦大学高分子科学系 上海 200433)
  • 投稿日期:2007-11-06 修回日期:2007-12-20 发布日期:2008-05-28
  • 通讯作者: 汪长春

Preparation of Mono-Dispersed Fluorescent PMMA/GMA/DVB Polymer Microspheres with Different Sizes

LIU, Hong-Bo, WANG, Chang-Chun*   

  1. (Key Laboratory of Molecular Engineering of Polymers (Ministry of Education), Department of Macromolecular Science, Fudan University, Shanghai 200433)
  • Received:2007-11-06 Revised:2007-12-20 Published:2008-05-28
  • Contact: WANG, Chang-Chun

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1143

被引次数

35 | 6

采用无皂乳液聚合及种子无皂乳液聚合方法制备了200～800 nm四种不同尺寸的单分散PMMA/GMA/DVB (PMGD)复合微球. 用扫描电镜(SEM)和动态光散射(DLS)对粒径尺寸、形貌进行了表征. 实验发现单体滴加速度是影响种子无皂乳液聚合过程二次成核的关键因素. 用乙二胺对微球表面的环氧基团开环后, 通过在微球表面接枝树枝状PAMAM (d-PAMAM)达到微球表面的官能化的目的, 元素分析和红外光谱实验证明了微球表面d-PAMAM的存在. 最后利用微球表面的活性氨基与四甲基异硫氰酸罗丹明(TRITC)反应, 得到四种尺寸的水分散性的红色荧光微球.

关键词: 无皂乳液聚合, 种子无皂乳液聚合, 单分散, 树枝状聚酰胺胺(d-PAMAM), 荧光微球

Mono-dispersed PMMA/GMA/DVB (PMGD) microspheres with size ranging from 200 to 800 nm were synthesized by soap-free emulsion polymerization and seeded soap-free emulsion polymerization. The as-prepared microspheres were aminated by ethylenediamine. Afterwards, different generations of dendritic PAMAM were grafted onto the surface of the microspheres by repeated Michael additions and amination reactions, at last different-sized water-dispersible microspheres with red fluorescence could be prepared by covalently coupling tetramethyl rhodamine isothiocyanate. Scanning electron microscopy and dynamic light scattering showed that the microspheres were very uniform. Fourier transform-infrared spectroscopy and elemental analysis demonstrated that the dendritic PAMAM had been successfully grafted onto the surface of the microspheres.

Key words: soap-free emulsion polymerization, seeded soap-free emulsion polymerization, mono-dispersed, dendritic PAMAM (d-PAMAM), fluorescent microsphere