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化学学报
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化学学报 ›› 2002, Vol. 60 ›› Issue (2): 334-337. 上一篇    下一篇

研究论文

豆荚软珊瑚Lobophytum sp. 的次生代谢产物研究

何细新;苏镜娱;曾陇梅;杨小平;梁永钜   

  1. 中山大学化学化工学院.广州(510275);中山医科大学肿瘤研究所.广州(510000)
  • 发布日期:2002-02-15

Studies on the secondary metabolite of the soft coral Lobophytum sp.

He Xixin;Su Jingyu;Zeng Longmei;Yang Xiaoping;Liang Yongju   

  1. Zhongshan Univ, Sch Chem & Chem Engn.Guangzhou(510275);Sun Yat-sen Univ Med Sci., Cancer Res Inst.Guangzhou(510000)
  • Published:2002-02-15

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从海南岛三亚海域采集的软珊瑚Labophytumsp.中分离得五个甾醇苷(1)～(5)。通过波谱分析，确定它们的化学结构依次为3'-O-乙酰基-4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(1)，4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(2),4'-O-乙酰基-4-O-[β-D-吡喃木糖苷]-孕甾-20-烯-3β,4α-二醇(3),4'-O-乙酰基-4-O-[β-D-吡喃阿拉伯糖苷]-孕甾-20-烯-3β,4α-二醇(4)和4-O-[β-D-吡喃阿拉伯糖苷]-孕甾-20-烯-3β,4α-二醇(5),其中1为新化合物。体外细胞毒性实验表明：化合物(1),(2)和(5)对SKMG-4,Hep-G2和CNE2三种人体癌细胞具有抑制作用。

关键词: 豆荚软珊瑚, 细胞毒性试验, 甾醇, 波谱分析, 糖苷, 软珊瑚, 代谢物

Five steroidal glycsides (1)～(5) have been isolated from the soft coral Lobophytum sp. , collected from Sanya Bay, Hainan Island. Base on the spectroscopic methods, their structures were determined to be 3'-O-acetyl-4-O-[β-D-xylo- pyranosyl-oxy]-pregn-20-en-3β, 4α-diol (1), 4-O-[β-D-xylo- pyranosyloxy]-pregn-20-en-β, 4α-diol (2), 4'-O- acetyl-4-O- [β-D-xylo-pyranosyl-oxy]-pregn-20-en-3β, 4α-diol(3), 4'-O-acetyl-4-O-[β-D-arabino-pyranosyl-oxy]-pregn-20-en-3β, 4α- diol (4), and 4-O-[β-D-arabinopyranosyl-oxy]-pregn-20-en- 3β, 4α- diol (5). Among them, 1 is a new compound. Bioassay showed that 1, 2 and 5 displayed cytotoxicity against human SKMG-4, Hep-G2 and CNE2 cell lines in vitro.

Key words: CYTOTOXICITY TEST, STEROL, SPECTROMETRIC ANALYSIS, GLYCOSIDE, SOFT CORAL, METABOLITE

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