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化学学报
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化学学报 ›› 2010, Vol. 68 ›› Issue (07): 713-716. 上一篇    下一篇

研究简报

H3PO4/Zr(OH)4高效促进NBS对取代烷基苯的亲电溴代

阮礼波，刘烽，欧文华，毛海舫，潘仙华   

  1. (上海应用技术学院 香料香精技术与工程学院 上海 200235)
  • 投稿日期:2009-06-29 修回日期:2009-09-09 发布日期:2010-04-14
  • 通讯作者: 潘仙华 E-mail:panxh2008@gmail.com

Bromination of the Alkylbenzene Substrates with N-Bromosuccinimide/H3PO4/Zr(OH)4

Ruan Libo Liu Feng Ou Wenhua Mao Haifang Pan Xianhua   

  1. (School of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 200235)
  • Received:2009-06-29 Revised:2009-09-09 Published:2010-04-14

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使用固体酸H3PO4/Zr(OH)4催化NBS对取代烷基苯进行苯环溴代反应. 根据不同取代烷基苯的反应活性, 在乙腈中, 高产率(79%～96%)地得到了相应的苯环单溴代产物, 同时反应体系中无苄位溴代的副产物生成. 在反应过程中, 固体酸催化剂可以重复使用多次.

关键词: 亲电溴代, 固体酸, 取代苯

A new method of regioselective monobromination of the alkylbenzene substrates with N-bromosuccinimide promoted by solid acid H3PO4/Zr(OH)4 was developed. The reactions were smoothly carried out in CH3CN under reflux conditions to give monobromination products in excellent yields (79%～96%). The brominated products of side chain were not observed. Remarkably, the catalyst of the solid acid H3PO4/Zr(OH)4 could be recycled and reused many times.

Key words: bromination, solid acid, substituted alkylbenzene