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化学学报
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化学学报 ›› 2011, Vol. 69 ›› Issue (22): 2746-2750. 上一篇    下一篇

研究简报

几种手性化合物在纤维素衍生物涂敷的SBA-15手性固定相上的直接拆分

杜明霞，徐茂震，邵鑫，蒲锡鹏，李文智*   

  1. (聊城大学材料科学与工程学院 聊城 252059)
  • 投稿日期:2011-04-09 修回日期:2011-07-05 发布日期:2011-07-29
  • 通讯作者: 李文智 E-mail:liwenzhi@lcu.edu.cn

Enantioseparation of Chiral Compounds on SBA-15 Coated with Cellulose tris-(3,5-dimethylphenylcarbamates) as the Stationary Phase for High Performance Liquid Chromatography

DU Ming-Xia, XU Mao-Zhen, SHAO Xin, PU Xi-Peng, LI Wen-Zhi   

  1. (College of Materials Science and Engineering, Liaocheng University, Liaocheng 252059)
  • Received:2011-04-09 Revised:2011-07-05 Published:2011-07-29
  • Contact: LI Wen-Zhi E-mail:liwenzhi@lcu.edu.cn

PDF

1381

被引次数

19

以三嵌段聚醚P123为模板, 四乙氧基硅烷为前驱体, 在强酸性条件下合成了高比表面积、大孔径、微米级的球形SBA-15. 将纤维素-三(3,5-二甲基苯基氨基甲酸酯)(CDMPC)涂敷在氨丙基化的SBA-15微球上, 作为手性固定相, 在正相条件下直接拆分了七种不同类型的手性化合物. 实验发现, 与同样尺寸的CDMPC涂敷的氨丙基硅胶手性柱相比, 手性化合物在所制备的新型手性固定相上有较强的保留、具有较高的分离因子|新制备的手性固定相不仅有较好的渗透性, 而且具有较高的手性识别能力. 因此, 高比表面的介孔SBA-15微球适合作为手性色谱填料基质.

关键词: SBA-15, 纤维素-三(3,5-二甲基苯基氨基甲酸酯), 手性拆分

Cellulose-tris(3,5-dimethylphenylcarbamates) (CDMPC) coated on mesoporous silica SBA-15 (SBA@CDMPC) with a high surface area and large pore diameters was applied in chiral high performance liquid chromatography (HPLC). The direct enantioseparation of seven chiral compounds has been achieved using n-hexane/alcohol as the mobile phase. Chromatographic behavior of chiral compounds on SBA@CDMPC was compared with that on CDMPC coated on silica gel (SG@CDMPC) by hexane-isopropanol as the mobile phase. The result suggests that SBA@CDMPC shows high chiral recognition abilities in chiral HPLC. SBA@CDMPC is a suitable chiral stationary phase (CSP) for the optical resolution of a lot of racemates by HPLC.

Key words: SBA-15, cellulose tris-(3,5-dimethylphenylcarbamate), enantioseparation