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化学学报
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化学学报 ›› 1981, Vol. 39 ›› Issue (5): 421-426. 上一篇    下一篇

论文

芫花根有效成分的研究 Ⅱ.新的抗生育二萜芫花酯乙的分离与结构

王成瑞, 陈政雄, 应百平, 周炳南, 刘嘉森, 潘百川   

  1. 中国科学院上海药物研究所
  • 投稿日期:1979-06-11 发布日期:2013-06-03

STUDIES ON THE ACTIVE PRINCIPLES OF THE ROOT OF YUAN-HUA (DAPHNE GENKWA) Ⅱ. ISOLATION AND STRUCTURE OF A NEW ANTIFERTILE DITERPENE YUANHUADINE

WANG CHENG-RUI, CHEN ZHENG-XIONG, YING BAI-PING, ZHOU BING-NAN, LIU JIA-SEN, PAN BEI-CHUAN   

  1. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1979-06-11 Published:2013-06-03

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从瑞香科植物芫花的根中分得另一个新的二萜原酸酯——芫花酯乙,根据物理及化学数据将其结构定为1,并由芫花酯甲(2)经三步化学反应生成1的丙酮缩合物3。

A new diterpene orthoester, Yuanhuadine C32H43O10, M+m/z 686.2790, [a]D16.5+26.9°(c.0.046 OHCl3) was isolated from the root of Daphne genkwa Sieb.et Zucc. Thymelaeaceae).Its struoture was elucidated as 1 by spectral analyses and chemical transformations.The aoetonide of 1 was obtained as prismatio orystals, C36H46O10, M+m/z 626.3083, m.p.173-175℃, whioh was identified as 8 by direct oomparision with the authentio specimen obtained from yuanhuaoine (2) via its debenzoylation product 6, and the aoetnnide 6, followed by aoetylation of the C12H-OH group.Both 1 and 2 show a signifioant abortificient activity.