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化学学报
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化学学报 ›› 1981, Vol. 39 ›› Issue (3): 263-267. 上一篇    下一篇

论文

小檗胺酚羟基的烷基化

陈庆华, 鹿菊仙, 陈兰贵, 赵学文   

  1. 中国医学科学院卫生研究所, 北京
  • 投稿日期:1979-05-07 发布日期:2013-06-03

THE ALKYLATION OF PHENOLIC HYDROXYL GROUP IN BERBAMINE

CHEN QING-HUA, LU JU-XIAN, CHEN LAN-GUI, ZHAO XUE-WEN   

  1. Institute of Hygiene, Chinese Academy of Medical Sciences, Beijing
  • Received:1979-05-07 Published:2013-06-03

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本文探讨了小檗胺酚羟基烷基化方法并提出了草酸酯作为选择性烷基化反应的试剂.通过小檗胺钠盐与相应的草酸酯作用制得了小檗胺甲醚,乙醚,异丙醚.此方法具有制备方便、安全无毒的优点,它可以代替有毒易爆的重氮烷烃烷基化反应的经典方法.

A method concerning the selective alkylation of phenolic group in berbamine by means of dialkyl oxalate was reported. We succeeded in preparing methyl, ethyl and iso-propyl ethers of berbamine without N-alkylation by treating sodium berbaminate with the corresponding dialkyl oxalates.