A new lignan compound, sohisanhenol, has been isolated from the fruits of Yi-(Geng-Wu-Wei-Zi (Schisandra henryi Clarke) (Magnoliaceae),oolleoted from the Xin-yang district of Henan province. Its structure and conformation are established as Ⅰ_a and Ⅰ_b respectively, the absolute configurations as biphenyl(R),C₇(R) and C₈ (S).The conformation and absolute configuration of deoxyschisandrin are the same as that of schisanhenol, the results are shown in Ⅱ_b and Ⅱ_a. In studies on mice intoxicated by carbon tetrachloride and preliminary clinical trial of the pationts suffered from chronic virus hepatitis, sohisanhenol has been shown to be ineffective in loworing the serum glntamio-pyruvio transaminase level.