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化学学报
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化学学报 ›› 1978, Vol. 36 ›› Issue (2): 142-148. 上一篇    下一篇

论文

仙鹤草有效成分的研究——Ⅳ.仙鹤草酚类似物的合成

盖元珠, 李英, 虞佩琳, 郑亚平, 王德生, 陈一心, 李良泉   

  1. 中国科学院上海药物研究所
  • 投稿日期:1977-07-01 发布日期:2013-06-03

STUDIES ON THE ACTIVE PRINCIPLES OF SHIAN-HO-TSAO——Ⅳ. SYNTHESES OF THE ANALOGUES OF AGRIMOL

KAI YUAN-CHU, LI YING, YU PEI-LIN, CHENG YA-PING, WANG TE-SHENG, CHEN I-SIN, LI LIANG-CHUAN   

  1. Shanghai Institute of Materia Medica, Academia Sinica
  • Received:1977-07-01 Published:2013-06-03

PDF

792

被引次数

7

为寻找活性高、毒性低、结构简单、易于制备的仙鹤草酚类似化合物,合成了一系列酰基间苯三酚衍生物的二缩合体化合物.初步动物试验结果表明化合物15,26与仙鹤草酚的抗疟活性相近.

A series of dimeric acylphlorogluoinol derivatives have been synthesized for the purpose of finding analogues of agrimols which might possess higher pharmacological activity, lower toxicity and are more readily synthesized as compared with agrimols.Preliminary pharmacological examination revealed that compounds 15 and 26 approached agrimols in antimalaiial activity.