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化学学报
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化学学报 ›› 1976, Vol. 34 ›› Issue (2): 133-142. 上一篇    下一篇

论文

创新霉素的全合成

张致平, 许先栋, 黄龙珍, 林吟卿, 李河水, 余志立, 赵春兰   

  1. 中国医学科学院药物研究所
  • 投稿日期:1976-05-12 发布日期:2013-06-03

THE TOTAL SYNTHESIS OF CHUANGHSINMYCIN

CHANG CHI-PING, HSU HSIEN-DONG, HUANG LUNG-CHEN, LIN YIN-CHING, LI HO-SHUI, Yu CHI-LI, CHAO CHUN-LAN   

  1. Institute of Materia Medica, Chinese Academy of Medical Sciences
  • Received:1976-05-12 Published:2013-06-03

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创新霉素是由游动放线菌(Actinoplanes jinanensis n.sp.)产生的一种新抗菌素,它对部分革兰氏阳性及阴性细菌有抑制作用,初步临床结果表明它既对败血病,又对胆囊及泌尿感染具有一定的疗效,创新霉素的结构已经化学降解及光谱测定确定,本文报导了消旋创新霉素的全合成。

Chuanghsinmycin is a new antibiotic produced by Actinoplctnes jinanensis n.sp.,active against a number of Gram-positive and Gram-negative bacteria.Preliminary clinical results show that it displays certain efficacy in septicemia,as well as urinary and biliary infections.The present paper reports the total synthesis of(±) Chuanghsinmycin.