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化学学报
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化学学报 ›› 1975, Vol. 33 ›› Issue (1): 35-47. 上一篇    下一篇

论文

川楝素的化学结构

钟炽昌1, 谢晶曦2, 陈淑凤2, 梁晓天2   

  1. 1. 四川中药研究所;
    2. 中国医学科学院药物研究所
  • 投稿日期:1974-02-27 发布日期:2013-06-03

THE STRUCTURE OF CHUANLIANSU

CHUNG CHI-CHANG1, HSIE TSING-HIS2, CHEN SHU-FENG2, LIANG HSIAO-TIEN2   

  1. 1. Szechwan Institute of Chinese Medicine;
    2. Institute of Matezia Medica, Chinese Academy of Medical Sciences
  • Received:1974-02-27 Published:2013-06-03

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被引次数

216

川楝素是从川楝树皮中提出的驱蛔活性成分,分子式为C30H38O11.含有二个乙酰氧基;三个游离羟基,其中一个与双键有烯丙醇关系;一个羰基处于乙酰氧基的邻位;还有β-单取代呋喃环和1,2环氧基等基团.为一呋喃三萜.通过化学反应及光谱分析,初步确定它的化学结构及其立体构型如Ⅰ式所示.

Chuanliansu (Ⅰ),CaogasW v isolated from the bark of Melia toosendan S: et Z., is an active anthelmintic against ascaris.The NMR spectrum of chuanliansu (Ⅰ) showed three quarternary C-methyl groups and two acetoxyl groups.Acetylation of Ⅰ with acetic anhydride and pyridine under forcing conditions yielded acetylchuanliansu (Ⅱ),C30H44O14 with a molecular weight of 700 as shown by mass spectrometry.