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化学学报
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化学学报 ›› 1965, Vol. 31 ›› Issue (5): 406-412. 上一篇    下一篇

论文

Ⅷ.O-乙基N, N-二乙氨基一(或二)硫代磷酸钠的制备及其化学反应

楊石先1,2, 陈天池1,2, 王琴孙1,2, 金桂玉1,2, 邵瑞鏈1,2, 刘綸祖1,2   

  1. 1. 南开大学元素有机化学研究所;
    2. 南开大学化学系
  • 投稿日期:1964-10-06 发布日期:2013-06-03

Ⅷ. THE PREPARATIONS AND CHEMICAL REACTIONS OF SODIUM SALTS OF O-ETHYL N, N-DIETHYL-PHOSPHOROAMIDO-MONO (OR DI) THIOACIDS

YANG SHIH-HsIEN1,2, CHEN TIEN-CHIH1,2, WANG CHIN-SuN1,2, CHIN KUEI-YU1,2, SHAW ZUI-LIEN1,2, LIU LUN-TSU1,2   

  1. Institute of Element-Organic Chemistry and Department of Chemistry, Nankai University
  • Received:1964-10-06 Published:2013-06-03

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1.本文报告以O-乙基N,N-二乙氨基硫代磷酰氯(Ⅲ)为原料,合成O-乙基N,N-二乙氨基一(或二)硫代磷酸钠(Ⅰ)、(Ⅱ)的方法。2.Ⅰ和Ⅱ分别与卤代烷反应,得到相应的酯(Ⅴ),(Ⅵ)。Ⅰ和Ⅱ在低温下用稀盐酸酸化则转化成相应的酸(Ⅶ)和(Ⅷ),后者分别与碘乙烷、重氮甲烷、环己胺等作用得到相应的酯(Ⅸ)和铵盐(Ⅺ)。3.Ⅱ与卤素(溴或碘)反应形成二硫化物(Ⅻ),后者与等量氯反应得到磷酰氯(Ⅲ)。

The preparations and chemical properties of the sodium salts of O-ethyl N,N-diethyl-phosphoroamido-mono(or di)-thioacids (Ⅰ and Ⅱ) were reported. Ⅰ or Ⅱ reacted with alkyl halides to give the corresponding alkyl esters (Ⅴ, Ⅵ). By acidifying with diluted hydrochloric acid, Ⅰ and Ⅱ were converted into their corres-ponding acids (Ⅶ, Ⅷ) which, on treatment with alkyl iodide in the presence of or-ganic bases, diazomethane and cyclohexylamine, were transformed into the corresponding alkyl esters (Ⅸ),methyl ester (Ⅹ) and amide salts (ⅩⅠ) respectively. Reaction of Ⅱ with bromine or iodine gave the disulfide (ⅩⅡ),which was transformed into the phosphoro-amidothionochloridate (Ⅲ) by reacting with chlorine.