化学学报 ›› 1964, Vol. 30 ›› Issue (3): 258-264. 上一篇    下一篇

论文

乙二胺三乙酸硫醚衍生物及其锑螯合物之研究

朱应麒, 汪润瑛, 张仁斌   

  1. 中国科学院药物研究所
  • 投稿日期:1963-05-29 修回日期:1964-01-10 发布日期:2013-06-03

SOME THIOETHER-CARRYING COMPLEXONES AND THEIR ANTIMONY CHELATES

CHU YING-CHI, WANG YUEN-YIN, CHANG JEN-PING   

  1. Institute of Materia Medica, Academia Sinica
  • Received:1963-05-29 Revised:1964-01-10 Published:2013-06-03

保持I中之乙二胺三乙酸的结构,而在其分子中引入硫醚基团,合成一系列N-(β-烷基硫代乙基)-N,N',N'-乙二胺三乙酸(VIa-d),希望能得到较I为强的螯合剂,并制备出其相应的锑盐.由观察所得锑盐的化学性质及其极谱研究,以及由于β-巯基乙胺三乙酸(Ⅶ)不能与锑生成稳定的螯合物等事实,说明硫醚键与锑原子间并不能形成强度与氮原子和锑原子间相当的配价键,因而初步假定(IVa-d)与锑螯合时仍为五配价的螯合剂.由研究结果,其锑螯合物的稳定性是按以下次序:(VId)>(VIc)>(VIb)>(VIa)

It was reported previously that N-benzylethylenediamine triacetic acid (Ⅰ), a pentadentate chelating agent, formed a rather unstable antimony complex[2].Since thioether is regarded as a donor group, and N-(β-methylthioethyl)N,N-diacetic acid (Ⅳ) formed more stable metal chelates than that of N-methyl-N,N-diacetic acid (Ⅴ)[8], it appears that the introduction of a thioether group into the ethylenediamine triacetic acid molecule would increase the stability of the antimony chelate by virtue of the formation of an additional coordination bond between sulphur and antimony atoms.For the same reason β-mercaptoethylamine triacetic acid (Ⅶ), the compound resulted from the replacement of one nitrogen atom by sulphur in the ethylenediamine triacetic acid molecule, would be a pentadentate chelating agent for antimony.