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化学学报
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化学学报 ›› 1963, Vol. 29 ›› Issue (5): 364-367. 上一篇    下一篇

研究简报

3β-乙酰氧基-5β, 6β-环氧-6α-甲基-25-D螺甾与三氟化硼的反应

周維善, 朱惠祥, 黄鳴龙   

  1. 中国科学院有机化学研究所
  • 投稿日期:1962-10-27 发布日期:2013-06-03

REACTION OF 3β-ACETOXY-5β, 6β-EPOXIDE-6α-METHYL-25D SPIROSTANE(Ⅲ) WITH BORON TRIFLUORIDE ETHERATE

CHOW WE1-ZAN, CHU WEI-SHANG, HUANG MINLON   

  1. Institute of Organic Chemistry, Academic Sinica
  • Received:1962-10-27 Published:2013-06-03

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3β-乙酰氧基-5β, 6β-环氧-6α-甲基-25D螺甾(Ⅲ)在与三氟化硼反应时按双竪鍵破环規律生成5α-氟-6β-羟基-6α-甲基化合物(Ⅳ), 产物經变为已知体(Ⅴ)証明其結构与构型.

3β-Acetoxy-5β, 6β-epoxide-6α-methyl-25D-spirostane(Ⅲ) when treated with boron trifluoride etherate yielded 5α-fluoro-6β-hydroxy-Ga-methyl derivative(Ⅳ), the structure and configuration of compound Ⅳ were proved by correlation with the known compound(Ⅴ).