化学学报 ›› 1963, Vol. 29 ›› Issue (2): 86-89. 上一篇    下一篇

论文

6-6-甲基螺甾内酯的合成

周維善   

  1. 中国科学院有机化学研究所
  • 投稿日期:1962-06-12 发布日期:2013-06-03

SYNTHESIS OF △6-6-METHYL SPIROLACTONE

CHOW WEI-ZAN   

  1. Institute of Organic Chemistry, Academia Sinica
  • Received:1962-06-12 Published:2013-06-03

6-6-甲基螺甾内酯(Ⅷ)可从环氧化合物(Ⅱ)经Grignard试剂一步加入6-甲基及侧链羧基,继用常法氢化、氧化、脱水、脱氢等步骤合成。

6-6-methyl spirolactone (VⅢ) was synthesized from epoxide (Ⅱ) through the following series of reaction, viz, Grignard synthesis with the introduction of 6-methyl and side chain carboxyl groups simultaneously, followed by catalytic hydrogenation, chromic acid oxidation, dehydration and dehydrogenation.L5