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化学学报
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化学学报 ›› 1961, Vol. 27 ›› Issue (1): 59-64. 上一篇    下一篇

论文

醛类与1, 2-二(对甲苯胺基)乙烷作用的研究Ⅰ.

屠世忠   

  1. 第二军医大学药学系
  • 投稿日期:1960-05-10 发布日期:2013-06-03

STUDIES ON THE REACTION BETWEEN ALDEHYDES AND 1, 2-BIS (p-TOLYL-AMINO) ETHANE Ⅰ.

TU SHIH-CHUNC   

  1. Department of Pharmacy, The 2nd Army Medical College, Shanghai
  • Received:1960-05-10 Published:2013-06-03

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1.用1,2-二(对甲苯胺基)乙烷与醛类缩合而得1,3-二(对甲苯基)-2-烃基四氢咪唑,在反应的专属性,缩合手续,产率及产物的熔点范围方面似均较前人用1,2-双苄胺基乙烷,1,2-二(对甲氧苄胺基)乙烷或1,2-二(对氯苄胺基)乙烷为佳.2.改进1,2-二(对甲苯胺基)乙烷的合成方法,使产量提高,并消除副反应.3.曾制备二十四种新的1,3-二(对甲苯基)-2-烃基四氢咪唑类化合物,和三种1,2-二(对甲苯胺基)乙烷的衍生物.4.1,3-二(对甲苯基)-2-邻硝基苯四氢咪唑可用稀盐酸分解为相应的邻硝基苯甲醛和1,2-二(对甲苯胺基)乙烷的二盐酸盐,其反应几为定量.

1. 1,2-Bis(b-tolvlamino)ethane has been found to be a more satisfactory and specific reagent for the characterization of aldehydes than 1,2-bis(benzylamino)ethane,1, 2-bis(p-methoxybenzylamino)ethane or 1,2-bis(p-chlorobenzylamino)ethane. It has also been found that the reaction between the reagent and acetone, acetophenone and some aldoses and ketoses is not noticeable.